Publications of Lorenzo Caputi

Caputi, L.; Franke, J.; Bussey, K.; Farrow, S. C.; Curcino Vieira, I. J.; Stevenson, C. E. M.; Lawson, D. M.; O’Connor, S. E.: Structural basis of cycloaddition in biosynthesis of iboga and Aspidosperma alkaloids. Nature Chemical Biology 16, pp. 383 - 386 (2020)

Davis, K.; Gkotsi, D. S.; Smith, D. R. M.; Goss, R. J. M.; Caputi, L.; O’Connor, S. E.: Nicotiana benthamiana as a transient expression host to produce auxin analogs. Frontiers in Plant Science 11, 581675 (2020)

Neumann, M.; Prahl, S.; Caputi, L.; Hill, L.; Kular, B.; Walter, A.; Patallo, E. P.; Milbredt, D.; Aires, A.; Schöpe, M. et al.; O’Connor, S. E.; van Pée, K.-H.; Ludwig-Müller, J.: Hairy root transformation of Brassica rapa with bacterial halogenase genes and regeneration to adult plants to modify production of indolic compounds. Phytochemistry 175, 112371 (2020)

Walter, A.; Caputi, L.; O’Connor, S.; van Pée, K.-H.; Ludwig-Müller, J.: Chlorinated auxins–how does Arabidopsis thaliana deal with them? International Journal of Molecular Sciences 21 (7), 2567 (2020)

Farrow, S. C.; Kamileen, M. O.; Caputi, L.; Bussey, K.; Mundy, J. E. A.; McAtee, R. C.; Stephenson, C. R. J.; O’Connor, S. E.: Biosynthesis of an anti-addiction agent from the iboga plant. Journal of the American Chemical Society 141 (33), pp. 12979 - 12983 (2019)

Yamamoto, K.; Takahashi, K.; Caputi, L.; Mizuno, H.; Rodriguez-Lopez, C. E.; Iwasaki, T.; Ishizaki, K.; Fukaki, H.; Ohnishi, M.; Yamazaki, M. et al.; Masujima, T.; O’Connor, S. E.; Mimura, T.: The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics. New Phytologist 224 (2), pp. 848 - 859 (2019)

Caputi, L.; Franke, J.; Farrow, S. C.; Chung, K.; Payne, R. M. E.; Nguyen, T.-D.; Dang, T.-T. T.; Carqueijeiro, I. S. T.; Koudounas, K.; de Bernonville, T. D. et al.; Ameyaw, B.; Jones, D. M.; Vieira, I. J. C.; Courdavault, V.; O'Connor, S. E.: Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science 360 (6394), pp. 1235 - 1238 (2018)

Sherden, N. H.; Lichman, B.; Caputi, L.; Zhao, D.; Kamileen, M. O.; Buell, C. R.; O'Connor, S. E.: Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry. Phytochemistry 145, pp. 48 - 56 (2018)

Stavrinides , A. K.; Tatsis , E. C.; Dang, T.-T.; Caputi, L.; Stevenson, C. E. M.; Lawson, D. M.; Schneider, B.; O'Connor, S. E.: Discovery of a short-chain dehydrogenase from Catharanthus roseus that produces a new monoterpene indole alkaloid. Chembiochem 19 (9), pp. 940 - 948 (2018)

Patallo, E. P.; Walter, A.; Milbredt, D.; Thomas, M.; Neumann, M.; Caputi, L.; O'Connor, S. E.; Ludwog-Müller, J.; van Pée, K.-H.: Strategies to produce chlorinated indole-3-acetic acid and indole-3-acetic acid intermediates. ChemistrySelect 2 (34), pp. 11148 - 11153 (2017)

Jakubczyk, D.; Caputi, L.; Stevenson, C. E. M.; Lawson, D. M.; O'Connor, S. E.: Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chemical Communications 52 (99), pp. 14306 - 14309 (2016)

Kries, H.; Caputi, L.; Stevenson, C. E. M.; Kamileen, M. O.; Sherden, N. H.; Geu-Flores, F.; Lawson, D. M.; O'Connor, S. E.: Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology 12 (1), pp. 6 - 8 (2016)

Stavrinides, A.; Tatsis, E. C.; Caputi, L.; Foureau, E.; Stevenson, C. E. M.; Lawson, D. M.; Courdavault, V.; O'Connor, S. E.: Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nature Communications 7, 12116 (2016)

Jakubczyk, D.; Caputi, L.; Hatsch, A.; Nielsen, C. A. F.; Diefenbacher, M.; Klein, J.; Molt, A.; Schroeder, H.; Cheng, J. Z.; Naesby, M. et al.; O'Connor, S. E.: Discovery and reconstitution of the cycloclavine biosynthetic pathwa—enzymatic formation of a cyclopropyl group. Angewandte Chemie International Edition 54 (17), pp. 5117 - 5121 (2015)

Stavrinides, A.; Tatsis, E. C.; Foureau, E.; Caputi, L.; Kellner, F.; Courdavault, V.; O'Connor, S. E.: Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism. Chemistry & Biology 22 (3), pp. 336 - 341 (2015)

Wagstaff, B. A.; Rejzek, M.; Pesnot, T.; Tedaldi, L. M.; Caputi, L.; O’Neill, E. C.; Benini, S.; Wagner, G. K.; Field, R. A.: Enzymatic synthesis of nucleobase-modified UDP-sugars: scope and limitations. Carbohydrate Research 404, pp. 17 - 25 (2015)

Wuerges, J.; Caputi, L.; Cianci, M.; Boivin, S.; Meijers, R.; Benini, S.: The crystal structure of Erwinia amylovora levansucrase provides a snapshot of the products of sucrose hydrolysis trapped into the active site. Journal of Structural Biology 191 (3), pp. 290 - 298 (2015)

Benini, S.; Caputi, L.; Cianci, M.: Cloning, purification, crystallization and 1.57 angstrom resolution X-ray data analysis of AmsI, the tyrosine phosphatase controlling amylovoran biosynthesis in the plant pathogen Erwinia amylovora. Acta Crystallographica Section F: Structural Biology and Crystallization Communications F70, pp. 1693 - 1696 (2014)

Caputi, L.; Cianci, M.; Benini, S.: Cloning, expression, purification, crystallization and preliminary X-ray analysis of EaLsc, a levansucrase from Erwinia amylovora. Acta Crystallographica Section F: Structural Biology and Crystallization Communications F69, pp. 570 - 573 (2013)

Caputi, L.; Nepogodiev, S. A.; Malnoy, M.; Rejzek, M.; Field, R. A.; Benini, S.: Biomolecular characterization of the levansucrase of Erwinia amylovora, a promising biocatalyst for the synthesis of fructooligosaccharides. Journal of Agricultural and Food Chemistry 61 (50), pp. 12265 - 12273 (2013)