Publications of Sarah E. O’Connor

Grzech, D.; Hong, B.; Caputi, L.; Sonawane, P. D.; O’Connor, S. E.: Engineering the biosynthesis of late-stage vinblastine precursors precondylocarpine acetate, catharanthine, tabersonine in Nicotiana benthamiana. ACS Synthetic Biology 12 (1), pp. 27 - 34 (2023)

Kunert, M.; Langley, C.; Lucier, R.; Ploß, K.; Rodriguez Lopez, C. E.; Serna Guerrero, D. A.; Rothe, E.; O’Connor, S. E.; Sonawane, P. D.: Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants. Nature Plants (2023)

Laforest, L. C.; Kuntz, M. A.; Kanumuri, S. R. R.; Mukhopadhyay, S.; Sharma, A.; O’Connor, S. E.; McCurdy, C. R.; Nadakuduti, S. S.: Metabolite and molecular characterization of Mitragyna speciosa identifies developmental and genotypic effects on monoterpene indole and oxindole alkaloid composition. Journal of Natural Products 86 (4), pp. 1042 - 1052 (2023)

Lawas, L. M. F.; Kamileen, M. O.; Buell, C. R.; O’Connor, S. E.; Leisner, C. P.: Transcriptome-based identification and functional characterization of iridoid synthase involved in monotropein biosynthesis in blueberry. Plant Direct 7 (7), e512 (2023)

Li, C.; Wood, J. C.; Vu, H. A.; Hamilton, J. P.; Lopez, C. E. R.; Payne, R. M. E.; Serna Guerrero, D. A.; Gase, K.; Yamamoto, K.; Vaillancourt, B. et al.; Caputi, L.; O’Connor, S. E.; Buell, C. R.: Single-cell multi-omics in the medicinal plant Catharanthus roseus. Nature Chemical Biology 19, pp. 1031 - 1041 (2023)

Lorensen, M. D. B. B.; Bjarnholt, N.; St-Pierre, B.; Heinicke, S.; Courdavault, V.; O’Connor, S. E.; Janfelt, C.: Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging. Phytochemistry 209, 113620 (2023)

Schäfer, E.; Seibold, P. S.; Bartram, S.; Trottmann, F.; Haensch, V. G.; Gressler, M.; Chadeayne, A. R.; Hertweck, C.; O’Connor, S. E.; Hoffmeister, D.: A „magic mushroom“ multi-product sesquiterpene synthase. ChemBioChem: A European Journal of Chemical Biology (accepted)

Schotte, C.; Jiang, Y.; Grzech, D.; Dang, T.-T. T.; Laforest, L. C.; León, F.; Mottinelli, M.; Nadakuduti, S. S.; McCurdy, C. R.; O’Connor, S. E.: Directed biosynthesis of mitragynine stereoisomers. Journal of the American Chemical Society 145 (9), pp. 4957 - 4963 (2023)

Sonawane, P. D.; Gharat, S. A.; Jozwiak, A.; Barbole, R.; Heinicke, S.; Almekias-Siegl, E.; Meir, S.; Rogachev, I.; O’Connor, S. E.; Giri, A. P. et al.; Aharoni, A.: A BAHD-type acyltransferase concludes the biosynthetic pathway of non-bitter glycoalkaloids in ripe tomato fruit. Nature Communications 14, 4540 (2023)

Stephan, P.; Langley, C.; Winkler, D.; Basquin, D. J.; Caputi, L.; O’Connor, S. E.; Kries, D. H.: Gerichtete Evolution von Piperazinsäureeinbau durch eine Nichtribosomale Peptidsynthetase. Angewandte Chemie 135 (35), e202304843 (2023)

Stephan, P.; Langley, C.; Winkler, D.; Basquin, J.; Caputi, L.; O’Connor, S. E.; Kries, H.: Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase. Angewandte Chemie International Edition 62 (35), e202304843 (2023)

Boccia, M.; Grzech, D.; Lopes, A. A.; O’Connor, S. E.; Caputi, L.: Directed biosynthesis of new to nature alkaloids in a heterologous Nicotiana benthamiana expression host. Frontiers in Plant Science 13, 919443 (2022)

Cuello, C.; Stander, E. A.; Jansen, H. J.; Dugé De Bernonville, T.; Lanoue, A.; Giglioli-Guivarch, N.; Papon, N.; Dirks, R. P.; Jensen, M. K.; O’Connor, S. E. et al.; Bessau, S.; Courdavault, V.: Genome assembly of the medicinal plant Voacanga thouarsii. Genome Biology and Evolution 14 (11), evac158 (2022)

DeMars, M.; Nakamura, Y.; Kamileen, M. O.; Sanders, J. N.; Paetz, C.; Houk, K. N.; O’Connor, S. E.: Mechanism and evolution of [4+2] cyclases in monoterpene indole alkaloid biosynthesis. Faseb Journal 36 (S1) (2022)

Dudley, Q. M.; Jo, S.; Serna Guerrero, D. A.; Chhetry, M.; Smedley, M. A.; Harwood, W. A.; Sherden, N. H.; O’Connor, S. E.; Caputi, L.; Patron, N. J.: Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana. Communications Biology 5, 949 (2022)

Hernández-Lozada, N. J.; Hong, B.; Wood, J. C.; Caputi, L.; Basquin, J.; Chuang, L.; Kunert, M.; Rodriguez Lopez, C. E.; Langley, C.; Zhao, D. et al.; Buell, C. R.; Lichman, B. R.; O’Connor, S. E.: Biocatalytic routes to stereo-divergent iridoids. Nature Communications 13, 4718 (2022)

Hong, B.; Grzech, D.; Caputi, L.; Sonawane, P. D.; Rodriguez Lopez, C. E.; Kamileen, M. O.; Hernández-Lozada, N. J.; O’Connor, S. E.: Biosynthesis of strychnine. Nature 607, pp. 617 - 622 (2022)

Kamileen, M. O.; DeMars II, M. D.; Hong, B.; Nakamura, Y.; Paetz, C.; Lichman, B. R.; Sonawane, P. D.; Caputi, L.; O’Connor, S. E.: Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in Pseudo-Aspidosperma alkaloid biosynthesis. Journal of the American Chemical Society 144 (42), pp. 19673 - 19579 (2022)

Köllner, T. G.; David, A.; Luck, K.; Beran, F.; Kunert, G.; Zhou, J.-J.; Caputi, L.; O’Connor, S. E.: Biosynthesis of iridoid sex pheromones in aphids. Proceedings of the National Academy of Sciences of the United States of America 119 (42), e2211254119 (2022)

Koudounas, K.; Guirimand, G.; Hoyos, L. F. R.; Carqueijeiro, I.; Cruz, P. L.; Stander, E.; Kulagina, N.; Perrin, J.; Oudin, A.; Besseau, S. et al.; Lanoue, A.; Atehortùa, L.; St-Pierre, B.; Giglioli-Guivarc’h, N.; Papon, N.; O’Connor, S. E.; Courdavault, V.: Tonoplast and peroxisome targeting of gamma-tocopherol N-methyltransferase homologs involved in the synthesis of monoterpene indole alkaloids. Plant and Cell Physiology 63 (2), pcab160, pp. 200 - 216 (2022)