Publications of Lorenzo Caputi

Kamileen, M. O.; DeMars II, M. D.; Hong, B.; Nakamura, Y.; Paetz, C.; Lichman, B. R.; Sonawane, P. D.; Caputi, L.; O’Connor, S. E.: Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in Pseudo-Aspidosperma alkaloid biosynthesis. Journal of the American Chemical Society 144 (42), pp. 19673 - 19579 (2022)

Köllner, T. G.; David, A.; Luck, K.; Beran, F.; Kunert, G.; Zhou, J.-J.; Caputi, L.; O’Connor, S. E.: Biosynthesis of iridoid sex pheromones in aphids. Proceedings of the National Academy of Sciences of the United States of America 119 (42), e2211254119 (2022)

Langley, C.; Tatsis, E. E.; Hong, B.; Nakamura, Y.; Paetz, C.; Stevenson, C. E. M.; Basquin, J.; Lawson, D. M.; Caputi, L.; O’Connor, S. E.: Expansion of the catalytic repertoire of alcohol dehydrogenases in plant metabolism. Angewandte Chemie, International Edition in English, e202210934 (2022)

Dudley, Q. M.; Jo, S.; Serna Guerrero, D. A.; Chhetry, M.; Smedley, M. A.; Harwood, W. A.; Sherden, N. H.; O’Connor, S. E.; Caputi, L.; Patron, N. J.: Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana. Communications Biology 5, 949 (2022)

Hernández-Lozada, N. J.; Hong, B.; Wood, J. C.; Caputi, L.; Basquin, J.; Chuang, L.; Kunert, M.; Rodriguez Lopez, C. E.; Langley, C.; Zhao, D. et al.; Buell, C. R.; Lichman, B. R.; O’Connor, S. E.: Biocatalytic routes to stereo-divergent iridoids. Nature Communications 13, 4718 (2022)

Hong, B.; Grzech, D.; Caputi, L.; Sonawane, P. D.; Rodriguez Lopez, C. E.; Kamileen, M. O.; Hernández-Lozada, N. J.; O’Connor, S. E.: Biosynthesis of strychnine. Nature 607, pp. 617 - 622 (2022)

Boccia, M.; Grzech, D.; Lopes, A. A.; O’Connor, S. E.; Caputi, L.: Directed biosynthesis of new to nature alkaloids in a heterologous Nicotiana benthamiana expression host. Frontiers in Plant Science 13, 919443 (2022)

Yamamoto, K.; Grzech, D.; Koudounas, K.; Stander, E. A.; Caputi, L.; Mimura, T.; Courdavault, V.; O’Connor, S. E.: Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus. Plant Physiology 187 (2), pp. 846 - 857 (2021)

Davis, K.; Gkotsi, D. S.; Smith, D. R. M.; Goss, R. J. M.; Caputi, L.; O’Connor, S. E.: Nicotiana benthamiana as a transient expression host to produce auxin analogs. Frontiers in Plant Science 11, 581675 (2020)

Neumann, M.; Prahl, S.; Caputi, L.; Hill, L.; Kular, B.; Walter, A.; Patallo, E. P.; Milbredt, D.; Aires, A.; Schöpe, M. et al.; O’Connor, S. E.; van Pée, K.-H.; Ludwig-Müller, J.: Hairy root transformation of Brassica rapa with bacterial halogenase genes and regeneration to adult plants to modify production of indolic compounds. Phytochemistry 175, 112371 (2020)

Walter, A.; Caputi, L.; O’Connor, S.; van Pée, K.-H.; Ludwig-Müller, J.: Chlorinated auxins–how does Arabidopsis thaliana deal with them? International Journal of Molecular Sciences 21 (7), 2567 (2020)

Caputi, L.; Franke, J.; Bussey, K.; Farrow, S. C.; Curcino Vieira, I. J.; Stevenson, C. E. M.; Lawson, D. M.; O’Connor, S. E.: Structural basis of cycloaddition in biosynthesis of iboga and Aspidosperma alkaloids. Nature Chemical Biology 16, pp. 383 - 386 (2020)

Yamamoto, K.; Takahashi, K.; Caputi, L.; Mizuno, H.; Rodriguez-Lopez, C. E.; Iwasaki, T.; Ishizaki, K.; Fukaki, H.; Ohnishi, M.; Yamazaki, M. et al.; Masujima, T.; O’Connor, S. E.; Mimura, T.: The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics. New Phytologist 224 (2), pp. 848 - 859 (2019)

Farrow, S. C.; Kamileen, M. O.; Caputi, L.; Bussey, K.; Mundy, J. E. A.; McAtee, R. C.; Stephenson, C. R. J.; O’Connor, S. E.: Biosynthesis of an anti-addiction agent from the iboga plant. Journal of the American Chemical Society 141 (33), pp. 12979 - 12983 (2019)

Stavrinides , A. K.; Tatsis , E. C.; Dang, T.-T.; Caputi, L.; Stevenson, C. E. M.; Lawson, D. M.; Schneider, B.; O'Connor, S. E.: Discovery of a short-chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid. Chembiochem 19 (9), pp. 940 - 948 (2018)

Caputi, L.; Franke, J.; Farrow, S. C.; Chung, K.; Payne, R. M. E.; Nguyen, T.-D.; Dang, T.-T. T.; Carqueijeiro, I. S. T.; Koudounas, K.; de Bernonville, T. D. et al.; Ameyaw, B.; Jones, D. M.; Vieira, I. J. C.; Courdavault, V.; O'Connor, S. E.: Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science 360 (6394), pp. 1235 - 1238 (2018)

Sherden, N. H.; Lichman, B.; Caputi, L.; Zhao, D.; Kamileen, M. O.; Buell, C. R.; O'Connor, S. E.: Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry. Phytochemistry 145, pp. 48 - 56 (2018)

Patallo, E. P.; Walter, A.; Milbredt, D.; Thomas, M.; Neumann, M.; Caputi, L.; O'Connor, S. E.; Ludwog-Müller, J.; van Pée, K.-H.: Strategies to produce chlorinated indole-3-acetic acid and indole-3-acetic acid intermediates. ChemistrySelect 2 (34), pp. 11148 - 11153 (2017)

Jakubczyk, D.; Caputi, L.; Stevenson, C. E. M.; Lawson, D. M.; O'Connor, S. E.: Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chemical Communications 52 (99), pp. 14306 - 14309 (2016)

Kries, H.; Caputi, L.; Stevenson, C. E. M.; Kamileen, M. O.; Sherden, N. H.; Geu-Flores, F.; Lawson, D. M.; O'Connor, S. E.: Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology 12 (1), pp. 6 - 8 (2016)