Publications of Sarah E. O’Connor

Courdavault, V.; O’Connor, S. E.; Oudin, A.; Besseau, S.; Papon, N.: Towards the microbial production of plant-derived anticancer drugs. Trends in Cancer 6 (6), pp. 444 - 448 (2020)

Lichman, B. R.; Godden, G. T.; Hamilton, J. P.; Palmer, L.; Kamileen, M. O.; Zhao, D.; Vaillancourt, B.; Wood, J. C.; Sun, M.; Kinser, T. J. et al.; Henry, L. K.; Rodriguez Lopez, C. E.; Dudareva, N.; Soltis, D. E.; Soltis, P. S.; Buell, C. R.; O’Connor, S. E.: The evolutionary origins of the cat attractant nepetalactone in catnip. Science Advances 6 (20), eaba0721 (2020)

Walter, A.; Caputi, L.; O’Connor, S.; van Pée, K.-H.; Ludwig-Müller, J.: Chlorinated auxins–how does Arabidopsis thaliana deal with them? International Journal of Molecular Sciences 21 (7), 2567 (2020)

de Bernonville, T. D.; Papon, N.; Clastre, M.; O’Connor, S. E.; Courdavault, V.: Identifying missing biosynthesis enzymes of plant natural products. Trends in Pharmacological Sciences 41 (3), pp. 142 - 146 (2020)

Caputi, L.; Franke, J.; Bussey, K.; Farrow, S. C.; Curcino Vieira, I. J.; Stevenson, C. E. M.; Lawson, D. M.; O’Connor, S. E.: Structural basis of cycloaddition in biosynthesis of iboga and Aspidosperma alkaloids. Nature Chemical Biology 16, pp. 383 - 386 (2020)

Carqueijeiro, I.; Langley, C.; Grzech, D.; Koudounas, K.; Papon, N.; O’Connor, S. E.; Courdavault, V.: Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs. Current Opinion in Biotechnology 65, pp. 17 - 24 (2020)

Yamamoto, K.; Takahashi, K.; Caputi, L.; Mizuno, H.; Rodriguez-Lopez, C. E.; Iwasaki, T.; Ishizaki, K.; Fukaki, H.; Ohnishi, M.; Yamazaki, M. et al.; Masujima, T.; O’Connor, S. E.; Mimura, T.: The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics. New Phytologist 224 (2), pp. 848 - 859 (2019)

Lichman, B. R.; O’Connor, S. E.; Kries, H.: Biocatalytic strategies towards [4+2] cycloadditions. Chemistry – A European Journal 25 (28), pp. 6864 - 6877 (2019)

Farrow, S. C.; Kamileen, M. O.; Caputi, L.; Bussey, K.; Mundy, J. E. A.; McAtee, R. C.; Stephenson, C. R. J.; O’Connor, S. E.: Biosynthesis of an anti-addiction agent from the iboga plant. Journal of the American Chemical Society 141 (33), pp. 12979 - 12983 (2019)

Franke, J.; Kim, J.; Hamilton, J. P.; Zhao, D.; Pham, G. M.; Wiegert-Rininger, K.; Crisovan, E.; Newton, L.; Vaillancourt, B.; Tatsis, E. et al.; Buell, C. R.; O'Connor, S. E.: Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis. Chembiochem 20 (1), pp. 83 - 87 (2019)

Johnson, S. R.; Bhat, W. W.; Bibik, J.; Turmo, A.; Hamberger, B.; Mint Evolutionary Genomics Consortium; Hamberger, B.: A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae). Journal of Biological Chemistry 294 (4), pp. 1349 - 1362 (2019)

Lichman, B. R.; Kamileen, M. O.; Titchiner, G. R.; Saalbach, G.; Stevenson, C. E. M.; Lawson, D. M.; O'Connor, S. E.: Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis. Nature Chemical Biology 15, pp. 71 - 79 (2019)

Stavrinides , A. K.; Tatsis , E. C.; Dang, T.-T.; Caputi, L.; Stevenson, C. E. M.; Lawson, D. M.; Schneider, B.; O'Connor, S. E.: Discovery of a short-chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid. Chembiochem 19 (9), pp. 940 - 948 (2018)

Carqueijeiro, I.; de Bernonville, T. D.; Lanoue, A.; Dang, T.-T.; Teijaro, C.; Paetz, C.; Billet, K.; Mosquera, A.; Oudin, A.; Besseau, S. et al.; Papon, N.; Glévarec, G.; Atehortùa, L.; Clastre, M.; Giglioli-Guivarc'h, N.; Schneider, B.; St-Pierre, B.; Andrade, R. B.; O’Connor, S. E.; Courdavault, V.: A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids. The Plant Journal 49 (3), pp. 469 - 484 (2018)

Mint Evolutionary Genomics Consortium: Phylogenomic mining of the mints: elucidating evolution in a chemically diverse clade. Molecular Plant 11 (8), pp. 1084 - 1096 (2018)

Caputi, L.; Franke, J.; Farrow, S. C.; Chung, K.; Payne, R. M. E.; Nguyen, T.-D.; Dang, T.-T. T.; Carqueijeiro, I. S. T.; Koudounas, K.; de Bernonville, T. D. et al.; Ameyaw, B.; Jones, D. M.; Vieira, I. J. C.; Courdavault, V.; O'Connor, S. E.: Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science 360 (6394), pp. 1235 - 1238 (2018)

Carqueijeiro, I.; Brown, S.; Chung, K.; Dang, T.-T.; Walia, M.; Besseau, S.; de Bernonville, T. D.; Oudin, A.; Lanoue, A.; Billet, K. et al.; Munsch, T.; Koudounas, K.; Melin, C.; Godon, C.; Razafimandimby, B.; de Craene, J.-O.; Glévarec, G.; Marc, J.; Giglioli-Guivarc’h, N.; Clastre, M.; St-Pierre, B.; Papon, N.; Andrade, R. B.; O'Connor, S. E.; Courdavaulta, V.: Two tabersonine 6,7-epoxidases start synthesis of lochnericine-type alkaloids in Catharanthus roseus. Plant Physiology 177 (4), pp. 1473 - 1486 (2018)

Casini, A.; Chang, F.-Y.; Eluere, R.; King, A. M.; Young, E. M.; Dudley, Q. M.; Karim, A.; Pratt, K.; Bristol, C.; Forget, A. et al.; Ghodasara, A.; Warden-Rothman, R.; Gan, R.; Cristofaro, A.; Borujeni, A. E.; Ryu, M.-H.; Li, J.; Kwon, Y.-C.; Wang, H.; Tatsis, E.; Rodriguez-Lopez, C.; O'Connor, S. E.; Medema, M. H.; Fischbach, M. A.; Jewett, M. C.; Voigt, C.; Gordon, D. B.: A pressure test to make 10 molecules in 90 days: external evaluation of methods to engineer biology. Journal of the American Chemical Society 140 (12), pp. 4302 - 4316 (2018)

Dang, T.-T. T.; Franke, J.; Carqueijeiro, I. S. T.; Langley, C.; Courdavault, V.; O'Connor, S. E.: Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nature Chemical Biology 14 (8), pp. 760 - 763 (2018)

Farrow, S. C.; Kamileen, M. O.; Meades, J.; Ameyaw, B.; Xiao, Y.; O'Connor, S. E.: Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga. The Journal of Biological Chemistry 293 (36), pp. 13821 - 13833 (2018)