Dr. Sarah E. O'Connor (PhD, Massachusetts Institute of Technology, Cambridge, MA)

   Department of Natural Product Biosynthesis
 Phone:+49 (0)3641 57 1200Max Planck Institute for Chemical Ecology
 Fax:+49 (0)3641 57 1202Hans-Knöll-Straße 8
  emailD-07745 Jena

 Publications  Presentations  Awards  Teaching  help    to staff list 
1Carqueijeiro, I., Koudounas, K., de Bernonville, T. D., Sepúlveda, L. J., Mosquera, A., Bomzan, D. P., Oudin, A., Lanoue, A., Besseau, S., Cruz, P. L., Kulagina, N., Stander, E. A., Eymieux, S., Burlaud-Gaillard, J., Blanchard, E., Clastre, M., Atehortùa, L., St-Pierre, B., Giglioli-Guivarc’h, N., Papon, N., Nagegowda, D. A., O’Connor, S. E., Courdavault, V. (2021). Alternative splicing creates a pseudo-strictosidine beta-D-glucosidase modulating alkaloid synthesis in Catharanthus roseus. Plant Physiology, 185(3), 836-856. doi:10.1093/plphys/kiaa075. [SOC107] MPG.PuRE
2Courdavault, V., O’Connor, S. E., Jensen, M. K., Papon, N. (2021). Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits. Natural Product Reports. doi:10.1039/D0NP00092B. [SOC111] OPEN ACCESS gold MPG.PuRE
3O’Connor, S. E. (2021). Symbionts, peptides, and (no) Iron: How ants defend their fungal crop. ACS Central Science, 7(2), 225-227. doi:10.1021/acscentsci.1c00097. [SOC109] OPEN ACCESS gold MPG.PuRE
4Rodríguez-López, C. E., Hong, B., Paetz, C., Nakamura, Y., Koudounas, K., Passeri, V., Baldoni, L., Alagna, F., Calderini, O., O’Connor, S. E. (2021). Two bi-functional cytochrome P450 CYP72 enzymes from olive (Olea europaea) catalyze the oxidative C-C bond cleavage in the biosynthesis of secoxy-iridoids – flavor and quality determinants in olive oil. New Phytologist, 229(4), 2288-2301. doi:10.1111/nph.16975. [SOC106] OPEN ACCESS gelb MPG.PuRE
5Trenti, F., Yamamoto, K., Hong, B., Paetz, C., Nakamura, Y., O’Connor, S. E. (2021). Early and late steps of quinine biosynthesis. Organic Letters, 23(5), 1793-1797. doi:10.1021/acs.orglett.1c00206. [SOC110] OPEN ACCESS gelb MPG.PuRE
1Caputi, L., Franke, J., Bussey, K., Farrow, S. C., Curcino Vieira, I. J., Stevenson, C. E. M., Lawson, D. M., O’Connor, S. E. (2020). Structural basis of cycloaddition in biosynthesis of iboga and Aspidosperma alkaloids. Nature Chemical Biology, 16, 383-386. doi:10.1038/s41589-019-0460-x. [SOC095] OPEN ACCESS green MPG.PuRE
2Carqueijeiro, I., Langley, C., Grzech, D., Koudounas, K., Papon, N., O’Connor, S. E., Courdavault, V. (2020). Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs. Current Opinion in Biotechnology, 65, 17-24. doi:10.1016/j.copbio.2019.11.017. [SOC092] OPEN ACCESS gold MPG.PuRE
3Chung, K., O’Connor, S. E. (2020). Biosynthesis of Vinblastine. In H.-W. Liu, T. P. Begley (Eds.), Comprehensive Natural Products III: Chemistry and Biology (pp. 642-685). Amsterdam: Elsevier. [SOC089] MPG.PuRE
4Courdavault, V., Besseau, S., Oudin, A., Papon, N., O’Connor, S. E. (2020). Virus-induced gene silencing: hush genes to make them talk. Trends in Plant Science, 25(7), 714-715. doi:10.1016/j.tplants.2020.02.013. [SOC097] MPG.PuRE
5Courdavault, V., O’Connor, S. E., Oudin, A., Besseau, S., Papon, N. (2020). Towards the microbial production of plant-derived anticancer drugs. Trends in Cancer, 6(6), 444-448. doi:10.1016/j.trecan.2020.02.004. [SOC101] OPEN ACCESS gold MPG.PuRE
6Dávila-Lara, A., Rodríguez-López, C. E., O’Connor, S. E., Mithöfer, A. (2020). Metabolomics analysis reveals tissue-specific metabolite compositions in leaf blade and traps of carnivorous Nepenthes plants. International Journal of Molecular Sciences, 21(12): 4376. doi:10.3390/ijms21124376. [MIT018] OPEN ACCESS gold MPG.PuRE
7Davis, K., Gkotsi, D. S., Smith, D. R. M., Goss, R. J. M., Caputi, L., O’Connor, S. E. (2020). Nicotiana benthamiana as a transient expression host to produce auxin analogs. Frontiers in Plant Science, 11: 581675. doi:10.3389/fpls.2020.581675. [SOC108] OPEN ACCESS gold MPG.PuRE
8de Bernonville, T. D., Maury, S., Delaunay, A., Daviaud, C., Chaparro, C., Tost, J., O’Connor, S. E., Courdavault, V. (2020). Developmental methylome of the medicinal plant Catharanthus roseus unravels the tissue-specific control of the monoterpene indole alkaloid pathway by DNA methylation. International Journal of Molecular Sciences, 21(17): 6028. doi:10.3390/ijms21176028. [SOC103] OPEN ACCESS gold MPG.PuRE
9de Bernonville, T. D., Papon, N., Clastre, M., O’Connor, S. E., Courdavault, V. (2020). Identifying missing biosynthesis enzymes of plant natural products. Trends in Pharmacological Sciences, 41(3), 142-146. doi:10.1016/ [SOC091] OPEN ACCESS gold MPG.PuRE
10Lichman, B. R., Godden, G. T., Hamilton, J. P., Palmer, L., Kamileen, M. O., Zhao, D., Vaillancourt, B., Wood, J. C., Sun, M., Kinser, T. J., Henry, L. K., Rodriguez Lopez, C. E., Dudareva, N., Soltis, D. E., Soltis, P. S., Buell, C. R., O’Connor, S. E. (2020). The evolutionary origins of the cat attractant nepetalactone in catnip. Science Advances, 6(20): eaba0721. doi:10.1126/sciadv.aba0721. [SOC096] OPEN ACCESS gold MPG.PuRE
11Neumann, M., Prahl, S., Caputi, L., Hill, L., Kular, B., Walter, A., Patallo, E. P., Milbredt, D., Aires, A., Schöpe, M., O’Connor, S. E., van Pée, K.-H., Ludwig-Müller, J. (2020). Hairy root transformation of Brassica rapa with bacterial halogenase genes and regeneration to adult plants to modify production of indolic compounds. Phytochemistry, 175: 112371. doi:10.1016/j.phytochem.2020.112371. [SOC099] MPG.PuRE
12Nguyen, T.-D., O’Connor, S. E. (2020). The progesterone 5 beta-reductase/iridoid synthase family: A catalytic reservoir for specialized metabolism across land plants. ACS Chemical Biology, 15(7), 1780-1787. doi:10.1021/acschembio.0c00220. [SOC100] OPEN ACCESS gold MPG.PuRE
13Palmer, L., O’Connor, S. E. (2020). Virus-induced gene silencing in Nepeta. In V. Courdavault, S. Besseau (Eds.), Virus-Induced Gene Silencing in Plants (pp. 111-121). Luxemburg: Springer Science+Business Media. doi:10.1007/978-1-0716-0751-0_9. [SOC102] MPG.PuRE
14Stander, E. A., Sepúlveda, L. J., de Bernonville, T. D., Carqueijeiro, I., Koudounas, K., Cruz, P. L., Besseau, S., Lanoue, A., Papon, N., Giglioli-Guivarc’h, N., Dirks, R., O’Connor, S. E., Atehortùa, L., Oudin, A., Courdavault, V. (2020). Identifying genes involved in alkaloid biosynthesis in Vinca minor through transcriptomics and gene co-expression analysis. Biomolecules, 10(12): 1595. doi:10.3390/biom10121595. [SOC104] OPEN ACCESS gold MPG.PuRE
15Walia, M., Teijaro, C. N., Gardner, A., Tran, T., Kang, J., Zhao, S., O’Connor, S. E., Courdavault, V., Andrade, R. B. (2020). Synthesis of (-)-melodinine K: A case study of efficiency in natural product synthesis. Journal of Natural Products, 83(8), 2425-2433. doi:10.1021/acs.jnatprod.0c00310. [SOC105] MPG.PuRE
16Walter, A., Caputi, L., O’Connor, S., van Pée, K.-H., Ludwig-Müller, J. (2020). Chlorinated auxins–how does Arabidopsis thaliana deal with them? International Journal of Molecular Sciences, 21(7): 2567. doi:10.3390/ijms21072567. [SOC098] OPEN ACCESS gold MPG.PuRE
1Farrow, S. C., Kamileen, M. O., Caputi, L., Bussey, K., Mundy, J. E. A., McAtee, R. C., Stephenson, C. R. J., O’Connor, S. E. (2019). Biosynthesis of an anti-addiction agent from the iboga plant. Journal of the American Chemical Society, 141(33), 12979-12983. doi:10.1021/jacs.9b05999. [SOC088] OPEN ACCESS gold MPG.PuRE
2Franke, J., Kim, J., Hamilton, J. P., Zhao, D., Pham, G. M., Wiegert-Rininger, K., Crisovan, E., Newton, L., Vaillancourt, B., Tatsis, E., Buell, C. R., O'Connor, S. E. (2019). Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis. Chembiochem, 20(1), 83-87. doi:10.1002/cbic.201800592. [SOC076] MPG.PuRE
3Johnson, S. R., Bhat, W. W., Bibik, J., Turmo, A., Hamberger, B., Mint Evolutionary Genomics Consortium, Hamberger, B. (2019). A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae). Journal of Biological Chemistry, 294, 1349-1362. doi:10.1074/jbc.RA118.006025. [SOC094] OPEN ACCESS gelb MPG.PuRE
4Lichman, B. R., Kamileen, M. O., Titchiner, G. R., Saalbach, G., Stevenson, C. E. M., Lawson, D. M., O'Connor, S. E. (2019). Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis. Nature Chemical Biology, 15, 71-79. doi:10.1038/s41589-018-0185-2. [SOC070] MPG.PuRE
5Lichman, B. R., O’Connor, S. E., Kries, H. (2019). Biocatalytic strategies towards [4+2] cycloadditions. Chemistry – A European Journal, 25(28), 6864-6877. doi:10.1002/chem.201805412. [SOC090] MPG.PuRE
6Yamamoto, K., Takahashi, K., Caputi, L., Mizuno, H., Rodriguez-Lopez, C. E., Iwasaki, T., Ishizaki, K., Fukaki, H., Ohnishi, M., Yamazaki, M., Masujima, T., O’Connor, S. E., Mimura, T. (2019). The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics. New Phytologist, 224(2), 848-859. doi:10.1111/nph.16138. [SOC093] MPG.PuRE
1Caputi, L., Franke, J., Farrow, S. C., Chung, K., Payne, R. M. E., Nguyen, T.-D., Dang, T.-T.-T., Carqueijeiro, I. S. T., Koudounas, K., de Bernonville, T. D., Ameyaw, B., Jones, D. M., Vieira, I. J. C., Courdavault, V., O'Connor, S. E. (2018). Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science, 360(6394), 1235-1238. doi:10.1126/science.aat4100. [SOC080] MPG.PuRE
2Carqueijeiro, I., Brown, S., Chung, K., Dang, T.-T., Walia, M., Besseau, S., de Bernonville, T. D., Oudin, A., Lanoue, A., Billet, K., Munsch, T., Koudounas, K., Melin, C., Godon, C., Razafimandimby, B., de Craene, J.-O., Glévarec, G., Marc, J., Giglioli-Guivarc’h, N., Clastre, M., St-Pierre, B., Papon, N., Andrade, R. B., O'Connor, S. E., Courdavaulta, V. (2018). Two tabersonine 6,7-epoxidases start synthesis of lochnericine-type alkaloids in Catharanthus roseus. Plant Physiology, 177(4), 1473-1486. doi:10.1104/pp.18.00549. [SOC077] MPG.PuRE
3Carqueijeiro, I., de Bernonville, T. D., Lanoue, A., Dang, T.-T., Teijaro, C., Paetz, C., Billet, K., Mosquera, A., Oudin, A., Besseau, S., Papon, N., Glévarec, G., Atehortùa, L., Clastre, M., Giglioli-Guivarc'h, N., Schneider, B., St-Pierre, B., Andrade, R. B., O’Connor, S. E., Courdavault, V. (2018). A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids. The Plant Journal, 49(3), 469-484. doi:10.1111/tpj.13868. [NMR249] OPEN ACCESS gold MPG.PuRE
4Carqueijeiro, I., Sepúlveda, L. J., Mosquera, A., Payne, R., Corbin, C., Papon, N., de Bernonville, T. D., Besseau, S., Lanoue, A., Glévarec, G., Clastre, M., St-Pierre, B., Atehortùa, L., Giglioli-Guivarc’h, N., O'Connor, S. E., Oudin, A., Courdavault, a. V. (2018). Vacuole-targeted proteins: ins and outs of subcellular localization studies. In C. Pereira (Ed.), Plant Vacuolar Trafficking (pp. 33-54). New York City: Humania Press. doi:10.1007/978-1-4939-7856-4_4. [SOC078] MPG.PuRE
5Casini, A., Chang, F.-Y., Eluere, R., King, A. M., Young, E. M., Dudley, Q. M., Karim, A., Pratt, K., Bristol, C., Forget, A., Ghodasara, A., Warden-Rothman, R., Gan, R., Cristofaro, A., Borujeni, A. E., Ryu, M.-H., Li, J., Kwon, Y.-C., Wang, H., Tatsis, E., Rodriguez-Lopez, C., O'Connor, S. E., Medema, M. H., Fischbach, M. A., Jewett, M. C., Voigt, C., Gordon, D. B. (2018). A pressure test to make 10 molecules in 90 days: external evaluation of methods to engineer biology. Journal of the American Chemical Society, 140(12), 4302-4316. doi:10.1021/jacs.7b13292. [SOC081] MPG.PuRE
6Dang, T.-T.-T., Franke, J., Carqueijeiro, I. S. T., Langley, C., Courdavault, V., O'Connor, S. E. (2018). Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nature Chemical Biology, 14(8), 760-763. doi:10.1038/s41589-018-0078-4. [SOC068] MPG.PuRE
7Farrow, S. C., Kamileen, M. O., Meades, J., Ameyaw, B., Xiao, Y., O'Connor, S. E. (2018). Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga. The Journal of Biological Chemistry, 293(36), 13821-13833. doi:10.1074/jbc.RA118.004060. [SOC069] OPEN ACCESS gold MPG.PuRE
8Mint Evolutionary Genomics Consortium (2018). Phylogenomic mining of the mints: elucidating evolution in a chemically diverse clade. Molecular Plant, 11(8), 1084-1096. doi:10.1016/j.molp.2018.06.002. [SOC079] OPEN ACCESS gelb MPG.PuRE
9Sherden, N. H., Lichman, B., Caputi, L., Zhao, D., Kamileen, M. O., Buell, C. R., O'Connor, S. E. (2018). Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine Nepetalactone stereochemistry. Phytochemistry, 145, 48-56. doi:10.1016/j.phytochem.2017.10.004. [SOC082] OPEN ACCESS gold MPG.PuRE
10Stavrinides, A. K., Tatsis, E. C., Dang, T.-T., Caputi, L., Stevenson, C. E. M., Lawson, D. M., Schneider, B., O'Connor, S. E. (2018). Discovery of a short-chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid. Chembiochem, 19(9), 940-948. doi:10.1002/cbic.201700621. [NMR252] MPG.PuRE
1Dang, T.-T.-T., Franke, J., Tatsis, E., O'Connor, S. E. (2017). Dual catalytic activity of a cytochrome P450 controls bifurcation at a metabolic branch point of alkaloid biosynthesis in Rauwolfia serpentina. Angewandte Chemie International Edition, 56(32), 9440-9444. doi:10.1002/anie.201705010. [SOC067] OPEN ACCESS gold MPG.PuRE
2de Bernonville, T. D., Carqueijeiro, I., Lanoue, A., Lafontaine, F., Bel, P. S., Liesecke, F., Musset, K., Oudin, A., Glevarec, G., Pichon, O., Besseau, S., Clastre, M., St-Pierre, B., Flors, V., Maury, S., Huguet, E., O'Connor, S. E., Courdavault, V. (2017). Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses. Scientific Reports, 7: 40453. doi:10.1038/srep40453. [SOC065] OPEN ACCESS gold MPG.PuRE
3Kries, H., Kellner, F., Kamileen, M. O., O'Connor, S. E. (2017). Inverted stereocontrol of iridoid synthase in snapdragon. Journal of Biological Chemistry, 292(35), 14659-14667. doi:10.1074/jbc.M117.800979. [SOC084] OPEN ACCESS gelb MPG.PuRE
4Larsen, B., Fuller, V. L., Pollier, J., Moerkercke, A. V., Schweizer, F., Payne, R., Colinas, M., O'Connor, S. E., Goossens, A., Halkier, B. A. (2017). Identification of iridoid glucoside transporters in Catharanthus roseus. Plant and Cell Physiology, 58(9), 1507-1518. doi:10.1093/pcp/pcx097. [SOC085] OPEN ACCESS gelb MPG.PuRE
5Leisner, C. P., Kamileen, M. O., Conway, M. E., O'Connor, S. E., Buell, C. R. (2017). Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species. PLoS One, 12(6): e0179417. doi:10.1371/journal.pone.0179417. [SOC066] OPEN ACCESS gold MPG.PuRE
6Patallo, E. P., Walter, A., Milbredt, D., Thomas, M., Neumann, M., Caputi, L., O'Connor, S. E., Ludwog-Müller, J., van Pée, K.-H. (2017). Strategies to produce chlorinated indole-3-acetic acid and indole-3-acetic acid intermediates. ChemistrySelect, 2(34), 11148-11153. doi:10.1002/slct.201701933. [SOC083] MPG.PuRE
7Payne, R. M. E., Xu, D., Foureau, E., Carqueijeiro, M. I. S. T., Oudin, A., de Bernonville, T. D., Novak, V., Burow, M., Olsen, C.-E., Jones, D. M., Tatsis, E. C., Pendle, A., Halkier, B. A., Geu-Flores, F., Courdavault, V., Nour-Eldin, H. H., O’Connor, S. E. (2017). An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. Nature, 3: 16208. doi:10.1038/nplants.2016.208. [SOC086] MPG.PuRE
8Tatsis, E. C., Carqueijeiro, I., de Bernonville, T. D., Franke, J., Dang, T.-T.-T., Oudin, A., Lanoue, A., Lafontaine, F., Stavrinides, A. K., Clastre, M., Courdavault, V. S. E., O’Connor, S. E. (2017). A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate. Nature Communications, 8: 316. doi:10.1038/s41467-017-00154-x. [EXT640] OPEN ACCESS gold MPG.PuRE
1Alagna, F., Geu-Flores, F., Kries, H., Panara, F., Baldoni, L., O'Connor, S. E., Osbourn, A. (2016). Identification and characterization of the iridoid synthase involved in oleuropein biosynthesis in olive (Olea europaea) fruits. The Journal of Biological Chemistry, 291(11), 5542-5554. doi:10.1074/jbc.M115.701276. [SOC060] OPEN ACCESS gold MPG.PuRE
2Jakubczyk, D., Caputi, L., Stevenson, C. E. M., Lawson, D. M., O'Connor, S. E. (2016). Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chemical Communications, 52(99), 14306-14309. doi:10.1039/c6cc08438a. [SOC059] OPEN ACCESS gold MPG.PuRE
3Kries, H., Caputi, L., Stevenson, C. E. M., Kamileen, M. O., Sherden, N. H., Geu-Flores, F., Lawson, D. M., O'Connor, S. E. (2016). Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology, 12(1), 6-8. doi:10.1038/nchembio.1955. [SOC058] OPEN ACCESS gold MPG.PuRE
4Kries, H., O'Connor, S. E. (2016). Biocatalysts from alkaloid producing plants. Current Opinion in Chemical Biology, 31, 22-30. doi:10.1016/j.cbpa.2015.12.006. [SOC061] OPEN ACCESS gold MPG.PuRE
5O'Connor, S. E. (2016). Synthetic biology and metabolic engineering in plants and microbes. Part A: Metabolism in microbes. [SOC075] MPG.PuRE
6O'Connor, S. E. (2016). Synthetic biology and metabolic engineering in plants and microbes. Part B. Metabolism in plants. [SOC074] MPG.PuRE
7Parage, C., Foureau, E., Kellner, F., Burlat, V., Mahroug, S., Lanoue, A., Duge de Bernonville, T., Arias Londono, M., Carqueijeiro, I., Oudin, A., Besseau, S., Papon, N., Glevarec, G., Atehortua, L., Giglioli-Guivarc'h, N., St-Pierre, B., Clastre, M., O'Connor, S. E., Courdavault, V. (2016). Class II cytochrome P450 reductase governs the biosynthesis of alkaloids. Plant Physiology, 172(3), 1563-1577. doi:10.1104/pp.16.00801. [SOC063] OPEN ACCESS gold MPG.PuRE
8Stavrinides, A., Tatsis, E. C., Caputi, L., Foureau, E., Stevenson, C. E. M., Lawson, D. M., Courdavault, V., O'Connor, S. E. (2016). Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nature Communications, 7: 12116. doi:10.1038/ncomms12116. [SOC062] OPEN ACCESS gold MPG.PuRE
9Tatsis, E. C., O'Connor, S. E. (2016). New developments in engineering plant metabolic pathways. Current Opinion in Biotechnology, 42, 126-132. doi:10.1016/j.copbio.2016.04.012. [SOC064] MPG.PuRE
1Brown, S., Clastre, M., Courdavault, V., O'Connor, S. E. (2015). De novo production of the plant-derived alkaloid strictosidine in yeast. Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3205-3210. doi:10.1073/pnas.1423555112. [SOC051] OPEN ACCESS gold MPG.PuRE
2Brown, S., O'Connor, S. E. (2015). Halogenase engineering for the generation of new natural product analogues. Chembiochem, 16(15), 2129-2135. doi:10.1002/cbic.201500338. [SOC057] MPG.PuRE
3de Bernonville, T. D., Foureau, E., Parage, C., Lanoue, A., Clastre, M., Londono, M. A., Oudin, A., Houille, B., Papon, N., Besseau, S., Glevarec, G., Atehortua, L., Giglioli-Guivarc'h, N., St-Pierre, B., De Luca, V., O'Connor, S. E., Courdavault, V. (2015). Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. BMC Genomics, 16: 619. doi:10.1186/s12864-015-1678-y. [SOC055] OPEN ACCESS gold MPG.PuRE
4Jakubczyk, D., Caputi, L., Hatsch, A., Nielsen, C. A. F., Diefenbacher, M., Klein, J., Molt, A., Schroeder, H., Cheng, J. Z., Naesby, M., O'Connor, S. E. (2015). Discovery and reconstitution of the cycloclavine biosynthetic pathwa—enzymatic formation of a cyclopropyl group. Angewandte Chemie International Edition, 54(17), 5117-5121. doi:10.1002/anie.201410002. [SOC052] OPEN ACCESS gold MPG.PuRE
5Jakubczyk, D., O’Connor, S. E. (2015). Ergot alkaloids. In Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation (pp. 379-397). [SOC087] MPG.PuRE
6Kellner, F., Geu-Flores, F., Sherden, N. H., Brown, S., Foureau, E., Courdavault, V., O'Connor, S. E. (2015). Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the Aspidosperma and eburnamine alkaloids. Chemical Communications, 51(36), 7626-7628. doi:10.1039/c5cc01309g. [SOC048] MPG.PuRE
7Kellner, F., Kim, J., Clavijo, B. J., Hamilton, J. P., Childs, K. L., Vaillancourt, B., Cepela, J., Habermann, M., Steuernagel, B., Clissold, L., McLay, K., Buell, C. R., O'Connor, S. E. (2015). Genome-guided investigation of plant natural product biosynthesis. The Plant Journal, 82(4), 680-692. doi:10.1111/tpj.12827. [SOC054] OPEN ACCESS gold MPG.PuRE
8Munkert, J., Pollier, J., Miettinen, K., Van Moerkercke, A., Payne, R., Mueller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W., Goossens, A. (2015). Iridoid synthase activity is common among the plant progesterone 5ß-reductase family. Molecular Plant, 8(1), 136-152. doi:10.1016/j.molp.2014.11.005. [SOC050] OPEN ACCESS gold MPG.PuRE
9O'Connor, S. E. (2015). Engineering of secondary metabolism. In Annual Review of Genetics (pp. 71-94). Palo Alto, Calif.: Annual Reviews, Inc. [SOC049] MPG.PuRE
10Patron, N., Orzaez, D., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, A., Farre, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A. R., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D. G., Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R., O'Connor, S. E., Fox, S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P.-M., Loque, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ane, J.-M., Hamberger, B. R., Langdale, J., Stougaard, J., Bouwmeester, H., Udvardi, M., Murray, J. A. H., Ntoukakis, V., Schaefer, P., Denby, K., Edwards, K. J., Osbourn, A., Haseloff, J. (2015). Standards for plant synthetic biology: a common syntax for exchange of DNA parts. New Phytologist, 208(1), 13-19. doi:10.1111/nph.13532. [SOC056] OPEN ACCESS gold MPG.PuRE
11Stavrinides, A., Tatsis, E. C., Foureau, E., Caputi, L., Kellner, F., Courdavault, V., O'Connor, S. E. (2015). Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism. Chemistry & Biology, 22(3), 336-341. doi:10.1016/j.chembiol.2015.02.006. [SOC053] OPEN ACCESS gold MPG.PuRE
12Van Moerkercke, A., Steensma, P., Schweizer, D., Pollier, J., Gariboldi, I., Payne, A., Bossche, R. V., Miettinen, K., Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J., Goossens, A. (2015). The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Proceedings of the National Academy of Sciences of the United States of America, 112(26), 8130-8135. doi:10.1073/pnas.1504951112. [SOC072] OPEN ACCESS gold MPG.PuRE
1Jakubczyk, D., Cheng, J. Z., O'Connor, S. E. (2014). Biosynthesis of the ergot alkaloids. Natural Product Reports, 31(10), 1328-1338. doi:10.1039/c4np00062e. [SOC044] MPG.PuRE
2Lindner, S., Geu-Flores, F., Braese, S., Sherden, N. H., O'Connor, S. E. (2014). Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis. Chemistry & Biology, 21(11), 1452-1456. doi:10.1016/j.chembiol.2014.09.010. [SOC047] OPEN ACCESS gold MPG.PuRE
3Nielsen, C. A. F., Folly, C., Hatsch, A., Molt, A., Schroeder, H., O'Connor, S. E., Naesby, M. (2014). The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus. Microbial Cell Factories, 13: 95. doi:10.1186/s12934-014-0095-2. [SOC046] OPEN ACCESS gold MPG.PuRE
4O'Connor, S. E., Brutnell, T. P. (2014). Editorial overview: Growing the future: synthetic biology in plants. Current Opinion in Plant Biology, 19, IV-V. doi:10.1016/j.pbi.2014.05.005. [SOC045] MPG.PuRE
1Besseau, S., Kellner, F., Lanoue, A., Thamm, A. M., Salim, V., Schneider, B., Geu-Flores, F., Höfer, R., Guirimand, G., Guihur, A., Oudin, A., Glevarec, G., Foureau, E., Papon, N., Clastre, M., Giglioli-Guivarc’h, N., St-Pierre, B., Werck-Reichhart, D., Burlat, V., Luca, V. D., O'Connor, S. E., Courdavault, V. (2013). A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ dependent manner in Catharanthus roseus. Plant Physiology, 163(4), 1792-1803. doi:10.1104/pp.113.222828. [NMR203] OPEN ACCESS gold MPG.PuRE
2Glenn, W. S., Runguphan, W., O'Connor, S. E. (2013). Recent progress in the metabolic engineering of alkaloids in plant systems. Current Opinion in Biotechnology, 24(2), 354-365. doi:10.1016/j.copbio.2012.08.003. [SOC042] MPG.PuRE
3Runguphan, W., O'Connor, S. E. (2013). Diversification of monoterpene indole alkaloid analogs through cross-coupling. Organic Letters, 15(11), 2850-2853. doi:10.1021/ol401179k. [SOC043] MPG.PuRE
1DellaPenna, D., O'Connor, S. E. (2012). Plant gene clusters and opiates. Science, 336(6089), 1648-1649. doi:10.1126/science.1225473. [SOC039] MPG.PuRE
2Geu-Flores, F., Sherden, N. H., Courdavault, V., Burlat, V., Glenn, W. S., Wu, C., Nims, E., Cui, Y., O'Connor, S. E. (2012). An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. Nature, 492(7427), 138-142. doi:10.1038/nature11692. [SOC040] MPG.PuRE
3Gongora-Castillo, E., Childs, K. L., Fedewa, G., Hamilton, J. P., Liscombe, D. K., Magallanes-Lundback, M., Mandadi, K. K., Nims, E., Runguphan, W., Vaillancourt, B., Varbanova-Herde, M., DellaPenna, D., McKnight, T. D., O'Connor, S. E., Buell, C. R. (2012). Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species. PLoS One, 7(12): e52506. doi:10.1371/journal.pone.0052506. [SOC041] OPEN ACCESS gold MPG.PuRE
4O'Connor, S. E. (2012). Strategies for engineering plant natural products: the iridoid-derived monoterpene indole alkaloids of Catharanthus roseus. Methods in Enzymology, 515, 189-206. doi:10.1016/B978-0-12-394290-6.00009-4. [SOC036] MPG.PuRE
5Panjikar, S., Stoeckigt, J., O'Connor, S. E., Warzecha, H. (2012). The impact of structural biology on alkaloid biosynthesis research. Natural Product Reports, 29(10), 1176-1200. doi:10.1039/c2np20057k. [SOC035] MPG.PuRE
6Ruff, B. M., Braese, S., O'Connor, S. E. (2012). Biocatalytic production of tetrahydroisoquinolines. Tetrahedron Letters, 53(9), 1071-1074. doi:10.1016/j.tetlet.2011.12.089. [SOC037] MPG.PuRE
7Runguphan, W., Glenn, W. S., O'Connor, S. E. (2012). Redesign of a dioxygenase in morphine biosynthesis. Chemistry & Biology, 19(6), 674-678. doi:10.1016/j.chembiol.2012.04.017. [SOC038] OPEN ACCESS gold MPG.PuRE
1Giddings, L.-A., Liscombe, D. K., Hamilton, J. P., Childs, K. L., DellaPenna, D., Buell, C. R., O'Connor, S. E. (2011). A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus. The Journal of Biological Chemistry, 286(19), 16751-16757. doi:10.1074/jbc.M111.225383. [SOC030] OPEN ACCESS gold MPG.PuRE
2Glenn, W. S., Nims, E., O'Connor, S. E. (2011). Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor. Journal of the American Chemical Society, 133(48), 19346-19349. doi:10.1021/ja2089348. [SOC034] MPG.PuRE
3Goetz, K. E., Coyle, C. M., Cheng, J. Z., O'Connor, S. E., Panaccione, D. G. (2011). Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus. Current Genetics, 57(3), 201-211. doi:10.1007/s00294-011-0336-4. [SOC031] MPG.PuRE
4Hicks, M. A., Barber II, A. E., Giddings, L.-A., Caldwell, J., O'Connor, S. E., Babbitt, P. C. (2011). The evolution of function in strictosidine synthase-like proteins. Proteins: Structure, Function, and Bioinformatics, 79(11), 3082-3098. doi:10.1002/prot.23135. [SOC033] MPG.PuRE
5Liscombe, D. K., O'Connor, S. E. (2011). A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus. Phytochemistry, 72(16), 1969-1977. doi:10.1016/j.phytochem.2011.07.001. [SOC032] MPG.PuRE
1Bernhardt, P., Usera, A. R., O'Connor, S. E. (2010). Biocatalytic asymmetric formation of tetrahydro-beta-carbolines. Tetrahedron Letters, 51(33), 4400-4402. doi:10.1016/j.tetlet.2010.06.075. [SOC027] MPG.PuRE
2Cheng, J. Z., Coyle, C. M., Panaccione, D. G., O'Connor, S. E. (2010). A role for old yellow enzyme in ergot alkaloid biosynthesis. The Journal of Physical Chemistry B, 132(6), 1776-1777. doi:10.1021/ja910193p. [SOC025] MPG.PuRE
3Cheng, J. Z., Coyle, C. M., Panaccione, D. G., O'Connor, S. E. (2010). Controlling a structural branch point in ergot alkaloid biosynthesis. Journal of the American Chemical Society, 132(37), 12835-12837. doi:10.1021/ja105785p. [SOC028] MPG.PuRE
4Coyle, C. M., Cheng, J. Z., O'Connor, S. E., Panaccione, D. G. (2010). An old yellow enzyme gene controls the branch point between Aspergillus fumigatus and Claviceps purpurea ergot alkaloid pathways. Applied and Environmental Microbiology, 76(12), 3898-3903. doi:10.1128/AEM.02914-09. [SOC026] OPEN ACCESS gold MPG.PuRE
5Liscombe, D. K., Usera, A. R., O'Connor, S. E. (2010). Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 18793-18798. doi:10.1073/pnas.1009003107. [SOC071] OPEN ACCESS gold MPG.PuRE
6Runguphan, W., Qu, X., O'Connor, S. E. (2010). Integrating carbon-halogen bond formation into medicinal plant metabolism. Nature, 468, 461-464. doi:10.1038/nature09524. [SOC029] MPG.PuRE
1Bernhardt, P., O'Connor, S. E. (2009). Opportunities for enzyme engineering in natural product biosynthesis. Current Opinion in Chemical Biology, 13(1), 35-42. doi:10.1016/j.cbpa.2009.01.005. [SOC019] OPEN ACCESS gold MPG.PuRE
2Bernhardt, P., O'Connor, S. E. (2009). Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry. Tetrahedron Letters, 50(51), 7118-7120. doi:10.1016/j.tetlet.2009.09.171. [SOC023] MPG.PuRE
3Bernhardt, P., Yerkes, N., O'Connor, S. E. (2009). Bypassing stereoselectivity in the early steps of alkaloid biosynthesis. Organic & Biomolecular Chemistry, 7(20), 4166-4168. doi:10.1039/b916027m. [SOC017] OPEN ACCESS gold MPG.PuRE
4Friedrich, A., Brase, S., O'Connor, S. E. (2009). Synthesis of 4-, 5-, 6-, and 7-azidotryptamines. Tetrahedron Letters, 50(1), 75-76. doi:10.1016/j.tetlet.2008.10.091. [SOC018] OPEN ACCESS gold MPG.PuRE
5Lee, H.-Y., Yerkes, N., O'Connor, S. E. (2009). Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis. Chemistry & Biology, 16(12), 1225-1229. doi:10.1016/j.chembiol.2009.11.016. [SOC024] OPEN ACCESS gold MPG.PuRE
6Leonard, E., Runguphan, W., O'Connor, S. E., Prather, K. J. (2009). Opportunities in metabolic engineering to facilitate scalable alkaloid production. Nature Chemical Biology, 5(5), 292-300. doi:10.1038/nchembio.160. [SOC021] MPG.PuRE
7Runguphan, W., Maresh, J. J., O'Connor, S. E. (2009). Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture. Proceedings of the National Academy of Sciences of the United States of America, 106(33), 13673-13678. doi:10.1073/pnas.0903393106. [SOC073] OPEN ACCESS gold MPG.PuRE
8Runguphan, W., O'Connor, S. E. (2009). Metabolic reprogramming of periwinkle plant culture. Nature Chemical Biology, 5(3), 151-153. doi:10.1038/nchembio.141. [SOC020] OPEN ACCESS gold MPG.PuRE
9Usera, A. R., O'Connor, S. E. (2009). Mechanistic advances in plant natural product enzymes. Current Opinion in Chemical Biology, 13(4), 492-498. doi:10.1016/j.cbpa.2009.06.019. [SOC022] MPG.PuRE
1Maresh, J. J., Giddings, L.-A., Friedrich, A., Loris, E. A., Panjikar, S., Trout, B. L., Stoeckigt, J., Peters, B., O'Connor, S. E. (2008). Strictosidine synthase: Mechanism of a Pictet-Spengler catalyzing enzyme. Journal of the American Chemical Society, 130(2), 710-723. doi:10.1021/ja077190z. [SOC015] MPG.PuRE
2Yerkes, N., Wu, J. X., McCoy, E., Galan, M. C., Chen, S., O'Connor, S. E. (2008). Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis. Bioorganic & Medicinal Chemistry Letters, 18(10), 3095-3098. doi:10.1016/j.bmcl.2007.11.063. [SOC016] OPEN ACCESS gold MPG.PuRE
1Bernhardt, P., McCoy, E., O'Connor, S. E. (2007). Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle. Chemistry & Biology, 14(8), 888-897. doi:10.1016/j.chembiol.2007.07.008. [SOC014] OPEN ACCESS gold MPG.PuRE
2Galan, M. C., McCoy, E., O'Connor, S. E. (2007). Chemoselective derivatization of alkaloids in periwinkle. Chemical Communications, 21(31), 3249-3251. doi:10.1039/b708919h. [SOC013] MPG.PuRE
1Chen, S., Galan, M. C., Coltharp, C., O'Connor, S. E. (2006). Redesign of a central enzyme in alkaloid biosynthesis. Chemistry & Biology, 13(11), 1137-1141. doi:10.1016/j.chembiol.2006.10.009. [SOC010] OPEN ACCESS gold MPG.PuRE
2Galan, M. C., O'Connor, S. E. (2006). Semi-synthesis of secologanin analogues. Tetrahedron Letters, 47(10), 1563-1565. doi:10.1016/j.tetlet.2006.01.009. [SOC007] MPG.PuRE
3McCoy, E., Galan, M., O'Connor, S. E. (2006). Substrate specificity of strictosidine synthase. Bioorganic & Medicinal Chemistry Letters, 16(9), 2475-2478. doi:10.1016/j.bmcl.2006.01.098. [SOC008] MPG.PuRE
4McCoy, E., O'Connor, S. E. (2006). Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus. Journal of the American Chemical Society, 128(44), 14276-14277. doi:10.1021/ja066787w. [SOC011] MPG.PuRE
5O'Connor, S. E. (2006). Cyclization of natural products. Nature Chemical Biology, 2(10), 511-512. doi:10.1038/nchembio1006-511. [SOC009] MPG.PuRE
6O'Connor, S. E., Maresh, J. J. (2006). Chemistry and biology of monoterpene indole alkaloid biosynthesis. Natural Product Reports, 23(4), 532-547. doi:10.1039/b512615k. [SOC006] MPG.PuRE
1O'Connor, S. E. (2004). Aureolic acids: Similar antibiotics with different biosynthetic gene clusters. Chemistry & Biology, 11(1), 8-10. doi:10.1016/j.chembiol.2004.01.006. [SOC012] MPG.PuRE
1O'Connor, S. E., Pohlmann, J., Imperiali, B., Saskiawan, I., Yamamoto, K. (2001). Probing the effect of the outer saccharide residues of N-linked glycans on peptide conformation. Journal of the American Chemical Society, 123(25), 6187-6188. doi:10.1021/ja010094s. [SOC005] MPG.PuRE
1Imperiali, B., O'Connor, S. E. (1999). Effect of N-linked glycosylation on glycopeptide and glycoprotein structure. Current Opinion in Chemical Biology, 3(6), 643-649. doi:10.1016/S1367-5931(99)00021-6. [SOC004] MPG.PuRE
2Imperiali, B., O'Connor, S. E., Hendrickson, T., Kellenberger, C. (1999). Chemistry and biology of asparagine-linked glycosylation. Pure and Applied Chemistry, 71(5), 777-787. doi:10.1351/pac199971050777. [SOC003] MPG.PuRE
1Imperiali, B., O'Connor, S. E. (1998). The conformational basis of asparagine-linked glycosylation. Pure and Applied Chemistry, 70(1), 33-40. doi:10.1351/pac199870010033. [SOC001] MPG.PuRE
2O'Connor, S. E., Imperiali, B. (1998). A molecular basis for glycosylation-induced conformational switching. Chemistry & Biology, 5(8), 427-437. doi:10.1016/S1074-5521(98)90159-4. [SOC002] OPEN ACCESS gold MPG.PuRE