Dr. Natalie Wielsch

   Research Group Mass Spectrometry
 Phone:+49 (0)3641 57 1809Max Planck Institute for Chemical Ecology
 Fax:+49 (0)3641 57 1701Hans-Knöll-Straße 8
  emailD-07745 Jena

 Research  Publications  Presentations  Teaching  help    to staff list 
1Fischer, M. L., Wielsch, N., Heckel, D. G., Vilcinskas, A., Vogel, H. (2020). Context-dependent venom deployment and protein composition in two assassin bugs. Ecology and Evolution, 10(18), 9932-9947. doi:10.1002/ece3.6652. [HEC462] OPEN ACCESS gold MPG.PuRE
2López-Castillo, L. M., González-Leyzaola, A., Diaz-Flores-Rivera, M. F., Winkler, R., Wielsch, N., García-Lara, S. (2020). Modulation of aleurone peroxidases in kernels of insect-resistant maize (Zea mays L.; Pob84-C3R) after mechanical and insect damage. Frontiers in Plant Science, 11: 781. doi:10.3389/fpls.2020.00781. [MS206] OPEN ACCESS gold MPG.PuRE
3Vilcinskas, A., Schwabe, M., Brinkrolf, K., Plarre, R., Wielsch, N., Vogel, H. (2020). Larvae of the clothing moth Tineola bisselliella maintain gut bacteria that secrete enzyme cocktails to facilitate the digestion of keratin. Microorganisms, 8(9): 1415. doi:10.3390/microorganisms8091415. [HEC463] OPEN ACCESS gold MPG.PuRE
1Guo, H., Halitschke, R., Wielsch, N., Gase, K., Baldwin, I. T. (2019). Mate selection in self-compatible wild tobacco results from coordinated variation in homologous self-incompatibility genes. Current Biology, 27(12), 2020-2030. doi:10.1016/j.cub.2019.05.042. [ITB608] OPEN ACCESS gold MPG.PuRE
2Heidel-Fischer, H. M., Kirsch, R., Reichelt, M., Ahn, S.-J., Wielsch, N., Baxter, S. W., Heckel, D. G., Vogel, H., Kroymann, J. (2019). An insect counteradaptation against host plant defenses evolved through concerted neofunctionalization. Molecular Biology and Evolution, 36(5), 930-941. doi:10.1093/molbev/msz019. [HEC410] OPEN ACCESS gelb MPG.PuRE
3Özbek, R., Wielsch, N., Vogel, H., Lochnit, G., Foerster, F., Vilcinskas, A., von Reumont, B. M. (2019). Proteo-transcriptomic characterization of the venom from the endoparasitoid wasp Pimpla turionellae with aspects on its biology and evolution. Toxins, 11(12): 721. doi:10.3390/toxins11120721. [MS200] OPEN ACCESS gelb MPG.PuRE
4Schmidt, L., Wielsch, N., Wang, D., Boland, W., Burse, A. (2019). Tissue-specific profiling of membrane proteins in the salicin sequestering juveniles of the herbivorous leaf beetle, Chrysomela populi. Insect Biochemistry and Molecular Biology, 109, 81-91. doi:10.1016/j.ibmb.2019.03.009. [BOL715] MPG.PuRE
5Skaljac, M., Vogel, H., Wielsch, N., Mihajlovic, S., Vilcinskas, A. (2019). Transmission of a protease-secreting bacterial symbiont among pea aphids via host plants. Frontiers in Physiology, 10: 438. doi:10.3389/fphys.2019.00438. [HEC417] OPEN ACCESS gold MPG.PuRE
1Busch, A., Kunert, G., Wielsch, N., Pauchet, Y. (2018). Cellulose degradation in Gastrophysa viridula (Coleoptera: Chrysomelidae): functional characterization of two CAZymes belonging to glycoside hydrolase family 45 reveals a novel enzymatic activity. Insect Molecular Biology, 27(5), 633-650. doi:10.1111/imb.12500. [HEC393] MPG.PuRE
2Giddings Vassão, D., Wielsch, N., de Melo Moreira Gomes, A. M., Gebauer-Jung, S., Hupfer, Y., Svatoš, A., Gershenzon, J. (2018). Plant defensive ß-Glucosidases resist digestion and sustain activity in the gut of a lepidopteran herbivore. Frontiers in Plant Science, 9: 1389. doi:10.3389/fpls.2018.01389. [GER528] OPEN ACCESS gold MPG.PuRE
3Kirtzel, J., Madhavan, S., Wielsch, N., Blinne, A., Hupfer, Y., Linde, J., Krause, K., Svatoš, A., Kothe, E. (2018). Enzymatic bioweathering and metal mobilization from black slate by the basidiomycete Schizophyllum commune. Frontiers in Microbiology, 9: 2545. doi:10.3389/fmicb.2018.02545. [MS193] OPEN ACCESS gold MPG.PuRE
1Wiechmann, K., Müller, H., König, S., Wielsch, N., Svatoš, A., Jauch, J., Werz, O. (2017). Mitochondrial chaperonin HSP60 is the apoptosis-related target for myrtucommulone. Cell Chemical Biology, 24(5), 614-623. doi:10.1016/j.chembiol.2017.04.008. [MS186] MPG.PuRE
1Beran, F., Rahfeld, P., Luck, K., Nagel, R., Vogel, H., Wielsch, N., Irmisch, S., Ramasamy, S., Gershenzon, J., Heckel, D. G., Köllner, T. G. (2016). Novel family of terpene synthases evolved from trans-isoprenyl diphosphate synthases in a flea beetle. Proceedings of the National Academy of Sciences of the United States of America, 113(11), 2922-2927. doi:10.1073/pnas.1523468113. [BER005] OPEN ACCESS gold MPG.PuRE
2Gretscher, R., Streicher, P. E., Strauß, A., Wielsch, N., Stock, M., Wang, D., Boland, W., Burse, A. (2016). A common theme in extracellular fluids of beetles: extracellular superoxide dismutases crucial for balancing ROS in response to microbial challenge. Scientific Reports, 6: 24082. doi:10.1038/srep24082. [BOL631] OPEN ACCESS gold MPG.PuRE
3Jacobs, C., Steiger, S., Heckel, D. G., Wielsch, N., Vilcinskas, A., Vogel, H. (2016). Sex, offspring and carcass determine antimicrobial peptide expression in the burying beetle. Scientific Reports, 6: 25409. doi:10.1038/srep25409. [HEC333] OPEN ACCESS gold MPG.PuRE
4Luo, T., Krüger, T., Knüpfer, U., Kasper, L., Wielsch, N., Hube, B., Kortgen, A., Bauer, M., Giamarellos-Bourboulis, E. J., Dimopoulos, G., Brakhage, A. A., Kniemeyer, O. (2016). Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. Journal of Proteome Research, 15(8), 2394-2406. doi:10.1021/acs.jproteome.5b01065. [MS184] MPG.PuRE
1Badgaa, A., Büchler, R., Wielsch, N., Walde, M., Heintzmann, R., Pauchet, Y., Svatoš, A., Ploss, K., Boland, W. (2015). The green gut: Chlorophyll degradation in the gut of Spodoptora littoralis. Journal of Chemical Ecology, 41, 065-974. doi:10.1007/s10886-015-0636-0. [BOL632] MPG.PuRE
2Pauchet, Y., Wielsch, N., Wilkinson, P. A., Sakaluk, S. K., Svatoš, A., Ffrench-Constant, R. H., Hunt, J., Heckel, D. G. (2015). What’s in the gift? Towards a molecular dissection of nuptial feeding in a cricket. PLoS One, 10(10): e0140191. doi:10.1371/journal.pone.0140191. [HEC313] OPEN ACCESS gold MPG.PuRE
3Rahfeld, P., Häger, W., Kirsch, R., Pauls, G., Becker, T., Schulze, E., Wielsch, N., Wang, D., Groth, M., Brandt, W., Boland, W., Burse, A. (2015). Glandular beta-glucosidases in juvenile Chrysomelina leaf beetles support the evolution of a host-plant-dependent chemical defence. Insect Biochemistry and Molecular Biology, 58, 28-38. doi:10.1016/j.ibmb.2015.01.003. [BOL613] MPG.PuRE
4Weinhold, A., Wielsch, N., Svatoš, A., Baldwin, I. T. (2015). Label-free nanoUPLC-MSE based quantification of antimicrobial peptides from the leaf apoplast of Nicotiana attenuata. BMC Plant Biology, 25: 18. doi:10.1186/s12870-014-0398-9. [ITB481] OPEN ACCESS gold MPG.PuRE
5Wolfram, S., Wielsch, N., Hupfer, Y., Mönch, B., Lu-Walther, H.-W., Heintzmann, R., Werz, O., Svatoš, A., Pohnert, G. (2015). A metabolic probe-enabled strategy reveals uptake and protein targets of polyunsaturated aldehydes in the diatom Phaeodactylum tricornutum. PLoS One, 10(10): e0140927. doi:10.1371/journal.pone.0140927. [MS175] OPEN ACCESS gold MPG.PuRE
1Beran, F., Pauchet, Y., Kunert, G., Reichelt, M., Wielsch, N., Vogel, H., Reinecke, A., Svatoš, A., Mewis, I., Schmid, D., Ramasamy, S., Ulrichs, C., Hansson, B. S., Gershenzon, J., Heckel, D. G. (2014). Phyllotreta striolata flea beetles utilize host plant defense compounds to create their own glucosinolate-myrosinase system. Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7349-7354. doi:10.1073/pnas.1321781111. [BER001] OPEN ACCESS gold MPG.PuRE
2Heil, M., Barajas-Barron, A., Orona-Tamayo, D., Wielsch, N., Svatoš, A. (2014). Partner manipulation stabilises a horizontally transmitted mutualism. Ecology Letters, 17(2), 185-192. doi:10.1111/ele.12215. [MS153] MPG.PuRE
3Rahfeld, P., Kirsch, R., Kugel, S., Wielsch, N., Stock, M., Groth, M., Boland, W., Burse, A. (2014). Independently recruited oxidases from the glucose-methanol-choline oxidoreductase family enabled chemical defences in leaf beetle larvae (subtribe Chrysomelina) to evolve. Proceedings of the Royal Society B: Biological Sciences, 281(1788): 20140842. doi:10.1098/rspb.2014.0842. [BOL602] OPEN ACCESS gold MPG.PuRE
4Stanton, M., Ullmann-Zeunert, L., Wielsch, N., Bartram, S., Svatoš, A., Baldwin, I. T., Groten, K. (2014). Silencing ribulose-1,5-bisphosphate carboxylase/oxygenase expression does not disrupt nitrogen allocation to defense after simulated herbivory in Nicotiana attenuata. Plant Signaling & Behavior, 8(12): e27570. doi:10.4161/psb.27570. [ITB457] OPEN ACCESS gold MPG.PuRE
5Tuchina, O., Groh, K., Talarico, G., Müller, C. H. G., Wielsch, N., Hupfer, Y., Svatoš, A., Grosse-Wilde, E., Hansson, B. S. (2014). Morphology and histochemistry of the aesthetasc-associated epidermal glands in terrestrial hermit crabs of the genus Coenobita (Decapoda: Paguroidea). PLoS One, 9(5): e96430. doi:10.1371/journal.pone.0096430. [HAN221] OPEN ACCESS gold MPG.PuRE
1Guo, H., Wielsch, N., Hafke, J. B., Svatoš, A., Mithöfer, A., Boland, W. (2013). A porin-like protein from oral secretions of Spodoptera littoralis larvae induces defense-related early events in plant leaves. Insect Biochemistry and Molecular Biology, 43(9), 849-858. doi:10.1016/j.ibmb.2013.06.005. [BOL565] MPG.PuRE
2Orona-Tamayo, D., Wielsch, N., Blanco-Labra, A., Svatoš, A., Farias-Rodriguez, R., Heil, M. (2013). Exclusive rewards in mutualisms: ant proteases and plant protease inhibitors create a lock–key system to protect Acacia food bodies from exploitation. Molecular Ecology, 22(15), 4087-4100. doi:10.1111/mec.12320. [MS148] MPG.PuRE
3Orona-Tamayo, D., Wielsch, N., Escalante-Pérez, M., Svatos, A., Molina-Torres, J., Muck, A., Ramirez-Chávez, E., Ádame-Alvarez, R.-M., Heil, M. (2013). Short-term proteomic dynamics reveal metabolic factory for active extrafloral nectar secretion by Acacia cornigera ant-plants. The Plant Journal, 73(4), 546-554. doi:10.1111/tpj.12052. [MS145] OPEN ACCESS gold MPG.PuRE
4Richter, P., Weißflog, J., Wielsch, N., Svatoš, A., Pohnert, G. (2013). Functionalized bis-enol acetates as specific molecular probes for esterases. Chembiochem, 14(18), 2435-2438. doi:10.1002/cbic.201300556. [MS152] MPG.PuRE
5Seo, P. J., Wielsch, N., Kessler, D., Svatoš, A., Park, C.-M., Baldwin, I. T., Kim, S.-G. (2013). Natural variation in floral nectar proteins of two Nicotiana attenuata accessions. BMC Plant Biology, 13: 101. doi:10.1186/1471-2229-13-101. [ITB435] OPEN ACCESS gold MPG.PuRE
6Ullmann-Zeunert, L., Stanton, M., Wielsch, N., Bartram, S., Hummert, C., Svatoš, A., Baldwin, I. T., Groten, K. (2013). Quantification of growth-defense trade-offs in a common currency: nitrogen required for phenolamide biosynthesis is not derived from ribulose-1,5-bisphosphate carboxylase/oxygenase turnover. The Plant Journal, 75(3), 417-429. doi:10.1111/tpj.12210. [ITB421] OPEN ACCESS gold MPG.PuRE
1Bodemann, R. R., Rahfeld, P., Stock, M., Kunert, M., Wielsch, N., Groth, M., Frick, S., Boland, W., Burse, A. (2012). Precise RNAi mediated silencing of metabolic active proteins in the defence secretions of juvenile leaf beetles. Proceedings of the Royal Society B: Biological Sciences, 279(1745), 4126-4134. doi:10.1098/rspb.2012.1342. [BOL542] OPEN ACCESS gold MPG.PuRE
2Kirsch, R., Wielsch, N., Vogel, H., Svatos, A., Heckel, D. G., Pauchet, Y. (2012). Combining proteomics and transcriptome sequencing to identify active plant-cell-wall-degrading enzymes in a leaf beetle. BMC Genomics, 13: 587. doi:10.1186/1471-2164-13-587. [HEC236] OPEN ACCESS gold MPG.PuRE
3Ullmann-Zeunert, L., Muck, A., Wielsch, N., Hufsky, F., Stanton, M., Bartram, S., Böcker, S., Baldwin, I. T., Groten, K., Svatoš, A. (2012). Determination of 15N-incorporation into plant proteins and their absolute quantitation: a new tool to study nitrogen flux dynamics and protein pool sizes elicited by plant-herbivore interactions. Journal of Proteome Research, 11(10), 4947-4960. doi:10.1021/pr300465n. [MS139] MPG.PuRE
1Ma, H., Krock, B., Tillmann, U., Muck, A., Wielsch, N., Svatoš, A., Cembella, A. (2011). Isolation of activity and partial characterization of large non-proteinaceous lytic allelochemicals produced by the marine dinoflagellate Alexandrium tamarense. Harmful Algae, 11, 65-72. doi:10.1016/j.hal.2011.07.004. [MS131] MPG.PuRE
1Schlaitz, A.-L., Srayko, M., Dammermann, A., Quintin, S., Wielsch, N., MacLeod, I., de Robillard, Q., Zinke, A., Yates III, J. R., Müller-Reichert, T., Shevchenko, A., Oegema, K., Hyman, A. A. (2007). The RSA complex targets Protein Phosphatase 2A to centrosomes and regulates mitotic spindle assembly in C. elegans. Cell, 128(1), 115-127. doi:10.1016/j.cell.2006.10.050. [EXT478] OPEN ACCESS gold MPG.PuRE
1Šebela, M., Štosová, T., Havliš, J., Wielsch, N., Thomas, H., Zdráhal, Z., Shevchenko, A. (2006). Thermostable trypsin conjugates for high-throughput proteomics: synthesis and performance evaluation. Proteomics, 6(10), 2959-2963. doi:10.1002/pmic.200500576. [EXT479] MPG.PuRE