Anne-Kathrin Dietel

   Department of Bioorganic Chemistry
 Phone:+49 (0)3641 57 1213Max Planck Institute for Chemical Ecology
 Fax:+49 (0)3641 57 1202Hans-Knöll-Straße 8
  emailD-07745 Jena

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PhD Thesis

started in Oct 2012
Identifying the molecular causes for the commonly observed AT-bias in plasmid genomes
Friedrich-Schiller-Universität Jena, Biologisch Pharmazeutische Fakultät
Supervisor(s): Prof. Dr. C. Kost
Co-Supervisor(s): Dr. M. Kaltenpoth, Prof. Dr. G. Theißen

Master Thesis

Metabolic costs of copy number, size and GC-content of plasmids as model endosymbionts
Friedrich-Schiller-Universität Jena, Biologisch Pharmazeutische Fakultät
Supervisor(s): Dr. M. Kaltenpoth
Co-Supervisor(s): Prof. Dr. C. Kost, Prof. Dr. G. Theißen (Lehrstuhl für Genetik, FSU)

Endosymbiosis plays an important role in the evolution of a large variety of organisms and the generation of biological diversity. The genome of endosymbionts is commonly characterized by a nucleotide bias composition towards AT as well as a reduction of gene content and genome size. Presumably, this ‘genome erosion’ leads to a reduction of costs for nucleotide biosynthesis and gene expression. However, the hypothesis lacks experimental evidence since the endosymbiont-host-relationship is obligate and difficult to disentangle. In my project, I am using plasmids and their bacterial hosts as a tractable model system to study the molecular basis of the observed genome features.
last updated on 2015-04-20