Research Group Microbial Chemical Ecology, Dr. Dieter Spiteller



Y. Shao, D. Spiteller, X. Tang, L. Ping, C. Colesie, U. Münchberg, S. Bartram, B. Schneider, B. Büdel, J. Popp, D.G. Heckel , W. Boland, α- and β-carotene in the foregut of Spodoptera larvae feeding on a toxic food plant. Insect Biochem Mol Biol. 2011, 41, 273-281.

I. Schoenian, M. Spiteller, M., Ghaste, R. Wirth, H. Herz, D. Spiteller, Chemical basis of the synergism and antagonism in microbial communities in the nests of leaf cutting ants, Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 1955-1960.


L. Ye, D. Spiteller, R. Ullrich, W. Boland, J. Nüske, G. Diekert, Fluoride-dependent conversion of organic compounds mediated by manganese peroxidases in the absence of Mn2+-ions, Biochemistry 2010, 49, 7264-7271.

M. V. B. Dias, F. Huang, D. Y. Chirgadze, M. Tosin, D. Spiteller, E. F. Valentine, P. F. Leadlay, J. B. Spencer, T. L. Blundell, Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK, J. Biol. Chem. 2010, 285, 22495-22504.

S. D. Braun, J. Hofmann, A. Wensing, M. S. Ullrich, H. Weingart, B. Völksch, D. Spiteller, Identification of the biosynthetic gene cluster of 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93, Appl. Environ. Microbiol.2010; 76, 2500-2508.

D. Spiteller, How do fungus growing ants protect their fungus garden against infections? Wie schützen pilz-züchtende Ameisen ihren Pilzgarten vor Infektionen? Biospektrum 2010, 2, 161-163.


U. A. Sammer, B. Völksch, U. Möllmann, M. Schmidtke, P. Spiteller, M. Spiteller, D. Spiteller, 2-Amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine an effective peptide antibiotic from the epiphyte Pantoea agglomerans 48b/90, Appl. Environ. Microbiol. 2009, 75, 7710-7717.

S. D. Braun, J. Hofmann, A. Wensing, H. Weingart, M. S. Ullrich, D. Spiteller, B. Völksch, In vitro antibiosis by Pseudomonas syringae Pss22d, acting against the bacterial blight pathogen of soybean plants, does not influence in planta biocontrol. J. Phytopathol. 2009, 158, 288-295.

M. Tosin, D. Spiteller, J. B. Spencer, Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. ChemBioChem 2009, 10, 1714-1723.

S. Haeder, R. Wirth, H. Herz, D. Spiteller, Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4742-4746.

T.-L. Li, D. Spiteller, J. B. Spencer, Identification of a pentaketide stilbene produced by a type III poly­ketide synthase from Pinus sylvestris and characterisation of free coenzyme A intermediates. ChemBioChem2009, 10, 896-901.

B. Schulze, D. Spiteller, Capsaicin: tailored chemical defence against unwanted "frugivores". ChemBioChem 2009, 10, 428-429.


S. B. Braun, B. Völksch, J. Nüske, D. Spiteller, 3-Methylarginine from Pseudomonas syringae pv. syringae 22d/93 suppresses the bacterial blight caused by its close relative Pseudomonas syringae pv. glycinea. ChemBioChem 2008, 9, 1913-1920.

D. Spiteller, Encyclopaedia of Ecology, Elsevier (Hrsg. S. E. Jorgensen, B. D. Fath), Plant defense strategies. 2008, 2798-2811.

D. Spiteller, Encyclopaedia of Ecology, Elsevier (Hrsg. S. E. Jorgensen, B. D. Fath), Animal defense strategies. 2008,165-174.

D. Spiteller, Encyclopaedia of Ecology, Elsevier (Hrsg. S. E. Jorgensen, B. D. Fath), Marine and aquatic defence strategies. 2008, 844-852.

B. Schulze, D. Spiteller, Encyclopaedia of Ecology (Hrsg. S. E. Jorgensen, B. D. Fath), Elsevier, Counterdefence strategies - Evolution of defence strategies. 2008, 1438-1445.

D. Spiteller, P. Spiteller, Encyclopedia of Ecology (Hrsg. S. E. Jorgensen, B. D. Fath), Elsevier, Fungal defense strategies. 2008, 1702-1708.

D. Spiteller, Encyclopaedia of Ecology (Hrsg. S. E. Jorgensen, B. D. Fath), Elsevier, Microbial defence and defence by microbial symbionts. 2008, 2341-2347.

H. Hong, D. Spiteller, J. B. Spencer, Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization. Angew. Chem. Int. Ed. 2008, 47, 6028-6032.


A. Habel, D. Spiteller, W. Boland, α-Methylbenzylisocyanate a powerful derivatisation reagent for the chiral analysis of medium- and long chain aliphatic alcohols and hydroxy fatty acids. J. Chrom. A 2007, 1165, 192-190.

L. Ping, R. Büchler, J. Piel, A. Mithöfer, A. Svatoš, D. Spiteller, K. Dettner, B. Schlott, W. Boland, A Dps-like protein from insect gut bacteria catalyzes the reversible hydrolysis of N-acyl amino acids. Environ. Microbiol. 2007, 9, 1572-83.

F. Huang, D. Spiteller, N. A. Koorbanally, Y. Li, N. M. Llewellyn, J. B. Spencer, Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. ChemBioChem 2007, 8, 283-288.


F. Huang, S. F. Haydock, D. Spiteller, T. Mironenko, T.-L. Li, P. F. Leadlay, D. O’Hagan, J. B. Spencer, Characterisation of a locus involved in fluorometabolite biosynthesis in Streptomyces cattleya. Chem. Biol. 2006, 13, 475-484.

A. Baerga-Ortiz, B. Popovic, A. P. Siskos, H. O’Hare, D. Spiteller, M. G. Williams, N. Campillo, J. B. Spencer, P. F. Leadlay, Site-directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin-producing polyketide synthase. Chem. Biol. 2006, 13, 277-285.


A. P. Siskos, A. Baerga-Ortiz, S. Bali, V. Stein, H. Mamdani, D. Spiteller, B. Popovic, J. B. Spencer, J. Staunton, K. J. Weissman, P. F. Leadlay, Molecular basis of Clemer’s rules: Stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem. Biol. 2005, 12, 1145-1153.

D. Spiteller, C. L. Waterman, J. B. Spencer. A method for trapping intermediates of polyketide biosynthesis with a nonhydrolysable malonyl coenzyme A-analogue. Angew. Chem. Int. Ed. 2005, 44, 7079-7082.

F. Huang, S. F. Haydock, T. Mironenko, D. Spiteller, Y. Li, J. B. Spencer, The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233. Org. Biomol. Chem. 2005, 3, 1410-1419.


M. Frey, D. Spiteller, W. Boland, A. Gierl, Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects. Phytochem. 2004, 65, 1047-1055.

M. Maffei, S. Bossi, D. Spiteller, A. Mithöfer, W. Boland, Effects of feeding Spodoptera littoralis on lima bean leaves. I. Membrane potentials, intracellular calcium variations, oral secretions, and regurgitate components. Plant Physiol. 2004, 134, 1752-1762.

D. Spiteller, N. J. Oldham, W. Boland, N-(17-Phosphonooxylinolenoyl)-glutamine and N-(17-phosphonooxylinoleoyl)-glutamine from insect gut: the first backbone-phosphorylated fatty acid derivatives in nature. J. Org. Chem. 2004, 69, 1104-1109.


D. Spiteller, W. Boland, Identification and synthesis of (17S)-N-(17-acyloxyacyl)-glutamine; novel surfactants from oral secretions of lepidopteran larvae. J. Org. Chem. 2003, 68, 8743-8749.

W. Boland, D. Spiteller, L. Ping, J. Piel, Mikroorganismen schaffen die molekulare Grundlage für Umweltinteraktionen vieler Insekten. Max Planck Gesellschaft Jahrbuch. 2003.

L. Ping, D. Spiteller, W. Boland, Plant defense-inducing N-acylgutamines from insect guts: Structural diversity and microbe-assisted biosyntheses. In: The BCPC International Congress - Crop Science & Technology 2003. Scottish Exhibition and Conference Centre. 2003, 1211-1216.

D. Spiteller, W. Boland, 15,16-Epoxylinoleoyl-L-glutamine and 15,16-dihydroxylinoleoyl-L-glutamine isolated from oral secretions of lepidopteran larvae. Tetrahedron 2003, 59, 135-139.


D. Spiteller, A. Jux, J. Piel, W. Boland, Feeding of [5,5-2H2]-1-desoxy-D-xylulose and [4,4,6,6,6-2H5]-mevalolactone to geosmin-producing Streptomyces spp. and Fossombronia pusilla. Phytochem. 2002, 61, 827-834.

W. Boland, D. Spiteller, Mikrobielle Symbionten von Insekten und ihre Bedeutung für die Pflanzen. In: Rundgespräche der Kommission für Ökologie, Bayerische Akademie der Wissenschaften. 2002, 23, 111-122.


C. Oldenburg, S. Kanaujia, D. Spiteller, N. J. Oldham, W. Boland, K.-E. Kaissling, Benzoic acid, a stimulant of odorant receptors of Bombyx mori, is rapidly metabolized to N-benzoylserine on the antennae. Chemoecology 2001, 11, 183-190.

W. Boland, D. Spiteller, Electronic Noses, In: Bioresponse-Linked Instrumental Analysis, Ed: B. Hock, Teubner Verlag, Stuttgart, Leipzig, Wiesbaden 2001, 57-78.

D. Spiteller, G. Pohnert, W. Boland, Absolute configuration of volicitin, an elicitor of plant volatile biosynthesis from lepidopteran larvae. Tetrahedron Lett. 2001, 42, 1483-1485.


D. Spiteller, K. Dettner, W. Boland, Gut bacteria may be involved in interactions between plants, herbivores and their predators: Microbial biosynthesis of N-acylglutamine surfactants as elicitors of plant volatiles. Biol. Chem. 2000, 381, 755-762.

G. Spiteller, D. Spiteller, W. Jira, U. Kießling, A. Dudda, M. Weisser, S. Hecht, C. Schwarz, Age and age-dependant diseases a consequence of lipid peroxidation. In: Peroxide Chemistry, Ed. W. Adam 2000, 179-208.

D. Spiteller, G. Spiteller, Identification of toxic 2,4-decadienal in oxidized low-density lipoprotein by solid-phase microextraction. Angew. Chem. Int. Ed. 2000, 39, 583-585.

D. Spiteller, G. Spiteller, Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis. Angew. Chem. Int. Ed. 2000, 39, 585-589.