Suyog Kuwar

   Department of Entomology
   Molecular Biology of the Insect Digestive System
 Phone:+49 (0)3641 57 1555Max Planck Institute for Chemical Ecology
 Fax:+49 (0)3641 57 1502Hans-Knöll-Straße 8
  emailD-07745 Jena

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PhD Thesis

started in Jan 2010
The adaptive response of the serine protease superfamily of the cotton bollworm, Helicoverpa armigera to dietary protease inhibitors
Friedrich-Schiller-Universität Jena, Biologisch-Pharmazeutische Fakultät
First Supervisor: Prof. D.G. Heckel
Co-Supervisor(s): Dr. Y. Pauchet, Prof. Dr. J. Gershenzon

Current Research (PhD Thesis):

Darwinian theory explains co-evolutionary interactions including predator/prey, host/parasite, and hostplant/herbivore in terms of sequential adaptations and counter-adaptations of the interacting species. In the struggle for survival in order to cope up with the challenges put forth by its hostplants, the herbivore employs different ways to overcome them by adapting various mechanisms. Elucidating the mechanisms of these adaptation or survival strategies is a challenging problem in evolutionary biology. Herbivorous insects utilize enzymes such as serine proteases of trypsin and chymotrypsin types for protein digestion, metabolism and development. Hence to defend against insect herbivores, plants express a variety of protease inhibitors to interfere with the process of digestion. Many insects respond adaptively to these inhibitors by shifting the spectrum of proteases they produce to favor forms that are inhibitor-resistant, however the mechanisms of adaptation are unknown. So our goal is to understand the regulation of dietary proteases of the generalist pest Helicoverpa armigera at the transcriptional and translational level in response to ingestion of protease inhibitors.
last updated on 2012-11-09