PhD Thesisstarted in Mar 2012
Target identification of bioactive signaling molecules by click chemistry
Friedrich-Schiller-Universität Jena, Chemisch-Geowissenschaftliche Fakultät
First Supervisor: Prof. Dr. W. Boland
Co-Supervisor(s): Dr. S. Bartram, Prof. Dr. R. Beckert (Institute of Organic Chemistry, FSU) The Asian ladybird Harmonia axyridis is natively distributed from the Altai Mountains to the Pacific Coast and from southern Siberia to southern China. It was also introduced as a biological control of various aphid species in North America and Europe but has become an invasive species there threatening the biodiversity of the native ladybirds. This invasive success is mainly because of its high resistance against a lot of pathogens. The resistance derives from harmonine, a diamino-compound found in the haemolymph of H. axyridis.
Although the investigation of the haemolymph was already started the biosynthesis and the degradation of harmonine have not been clarified yet. In cooperation with the working group of Prof. Dr. A. Vilcinskas (Fraunhofer Institute for Molecular Biology and Applied Ecology IME) the biosynthesis will be further illuminated. Therefor specifically labelled, possible precursors will be synthesized, fed to H. axyridis and by a combination of different analytical methods biosynthetic intermediates will be identified.
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