abva5077

Abith Vattekkatte

   
   Department of Bioorganic Chemistry
 Phone:+49 (0)3641 57 1259Max Planck Institute for Chemical Ecology
 Fax:-Hans-Knöll-Straße 8
  emailD-07745 Jena

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PhD Thesis

started in Feb 2011
Mechanisms of terpene biosynthesis in plants
Friedrich-Schiller-Universität Jena, Chemisch-Geowissenschaftliche Fakultät
First Supervisor: Prof. Dr. W. Boland
Co-Supervisor(s): Dr. S. Bartram, Prof. Dr. R. Beckert (FSU Jena, Organische Chemie)

Sesquiterpenes are one of the structurally diverse class of natural products isolated from plants, fungi, bacteria and marine invertebrates. Terpene synthases are responsible for a large diversity of terpene carbon skeletons found in nature. The multiproduct sesquiterpene synthase MtTPS5 isolated from Medicago truncatula produces 27 products from farnesyl diphosphate. I would like to study the structure of active site and follow the binding patterns and enzyme kinetics of enzyme by utilizing analogs of natural substrate. I would also like to utilize classical labeling experiments, the determination of the absolute configuration and the enantiomeric excess of individual products by chiral gas chromatography and site-directed mutagenesis to study the mechanism by the products formed.
last updated on 2013-04-02