VW Research Group Experimental Ecology and Evolution

    Microorganisms are well known to readily enter into synergistic interactions with both other micro- or macroorganisms. The molecular prerequisites and selective conditions that favour/ hamper the evolution of such cooperative interactions, however, remain poorly understood.

   Our main goal is to answer the question: Why do organisms cooperate with each other? For this, we use microorganisms as an experimentally tractable model. By rigorously and systematically studying the physiological and genetic causes as well as the ecological and evolutionary consequences of a cooperative lifestyle, we aim to contribute to the development of a solid, empirically-based framework that allows to mechanistically predict the evolution of cooperative behaviours within microbial communities.

   We address this fascinating research question by combining the methodological power of evolution experiments with recent advances in the field of molecular microbiology and synthetic systems biology. First, specific ecological interactions between different microorganisms are synthetically engineered. The rationale of this design is based on a priori knowledge on the essential features of the focal interaction and its genetic implementation is guided by computational approaches. Second, theoretical models are being developed that provide testable hypotheses, which are then experimentally verified by exposing precisely defined microbial consortia to certain environmental conditions or selection pressures. These experiments are either performed on ecological time-scales, to monitor fitness-related shifts in the frequency distributions of the interacting populations, or in long-term evolution experiments, during which new genotypes arise by mutation and selection. Finally, post-hoc analyses are performed to study the underlying processes on a phenotypic, a physiological, and a genetic level. This laboratory-based approach is complemented by the study of natural microbial populations, in which we verify the general applicability of our findings.

   Current research themes in our group are:

  • Synthetic microbial ecology

  • Evolution and maintenance of cooperative interactions

  • Coevolutionary dynamics within microbial communities

  • Bacteria-plasmid interactions

  • Evolution of metabolic networks

Dr. Christian Kost

 

Group Leader:

Dr. Christian Kost
+49 (0) 3641 57 1212
E-mail

Lab news



1.11.2012 Shraddha Shitut joins our group as a new PhD student. Welcome
                    Shraddha!


1.10.2012 Anne successfully defends her excellent diploma thesis "Metabolic costs of
                    copy number, size, and GC-content of plasmids as model endosymbionts".
                    Congratulations Anne!


Fortunately, we could convince Anne to stay a little longer and do her PhD in our group.


1.07.2012 Silvio Waschina joins the lab as a new PhD student that is cosupervised
                     by Christoph Kaleta and Christian Kost. Welcome back Silvio!

9.01.2012  Silvio successfully defends his excellent diploma thesis, which is entitled  "Theoretical design
                       and experimental verification of amino acid overproducing strains of Escherichia coli using
                       CASOP GS". Congratulations Silvio!


1.11.2011 The lab welcomes Daniel Preußger, who is joining us as a master
                      student. Welcome Daniel!

 

1.09.2011 Glen D'Souza joins the lab as a new PhD student. Welcome Glen!

30.08.2011 Tobias Weise hands in his bachelor's thesis, which is entitled: 'Aufbau und Inbetriebnahme
                       einer Chemostaten-Anlage zur Kokultivierung mutualistischer Bakterienstaemme'
.
                       Congratulations Tobias! Unfortunately Tobias leaves us to commence the Master's program
                       biotechnology at the FH Jena.


Martin Kaltenpoth and Christian Kost coorganize a symposium on "Mutualistic interactions: causes and consequences" at the ESEB conference 2011 in Tuebingen (more...)

18.05.2011 Sandra Scholz hands in her diploma thesis, which is entitled 'Establishing of a flexible labeling
                      strategy for soil bacteria with fluorescent proteins
'. Congratulations Sandra! She will now join
                       Axel Mithoefer's group for a PhD.


1.04.2011 Christian Kost becomes a faculty member of the International Max
                     Planck Research School (IMPRS) in Jena.


 28.02.2011 Tobias Weise and Silvio Waschina join the lab as a bachelor
                         and a diploma student respectively.

9.01.2011 The lab farewells Ingrid. It was great having you here.


01.11.2010  Anne-Kathrin Dietel joins the lab as a new master student. Welcome Anne.


15.09.2010 Ingrid Teich does an internship with us.

13.07.2010 Felix Bertels successfully defends his diploma thesis at the University of Applied Sciences.
                      Congratulations Felix!


08.07.2009 Our work is supported by an 'Advanced Postdoctoral
                       Fellowship' of the VolkswagenStiftung.


24.11.2009 The lab welcomes Sandra Scholz as a new diploma student.


05.11.2009 Christian Kost co-authors a paper on the evolution of bet-hedging (more...).


01.11.2009 Samay Pande joins the lab as a new JSMC-funded PhD student.
                       Welcome Samay!